Challenges and advances in quantum dot fluorescent probes to detect reactive oxygen and nitrogen species: A review

Oluwasesan Adegoke (Lead / Corresponding author), Patricia B. C. Forbes

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

The pathological and physiological effects of reactive oxygen and nitrogen species (ROS/RNS) have instigated increasing awareness in the scientific field with respect to the development of suitable probes for their detection. Among the various probes developed to date, semiconductor quantum dots (QDs) fluorescent probes have attracted significant attention. The unfavourable properties of ROS/RNS with respect to their detection, such as their short lifetimes and the competitive presence of various endogenous reactive species, capable of interfering with the probe in biological matrices, have hindered the effective performance of most probes as well as complicating the design of suitable probes. The development of novel QD fluorescent probes capable of circumventing these problems is thus, of scientific interest. In this review, we highlight the challenges faced, pros and cons and published developments to date, with respect to QD fluorescent probes for ROS/RNS such as H2O2, O2(·-), ·OH, HOCl, NO and ONOO(-).

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalAnalytica Chimica Acta
Volume862
Early online date23 Aug 2014
DOIs
Publication statusPublished - 3 Mar 2015

Keywords

  • Animals
  • Fluorescent Dyes/analysis
  • Humans
  • Quantum Dots
  • Reactive Nitrogen Species/analysis
  • Reactive Oxygen Species/analysis

Fingerprint Dive into the research topics of 'Challenges and advances in quantum dot fluorescent probes to detect reactive oxygen and nitrogen species: A review'. Together they form a unique fingerprint.

  • Cite this