Challenges and recent progress in drug discovery for tropical diseases

Research output: Contribution to journalReview article

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155 Downloads (Pure)

Abstract

Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.

Original languageEnglish
Pages (from-to)498-506
Number of pages9
JournalNature
Volume559
Issue number7715
DOIs
Publication statusPublished - 25 Jul 2018

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Drug Discovery
Pharmaceutical Preparations
Communicable Diseases
Economics
Morbidity
Mortality

Cite this

@article{220f9450806c4b76abbfb447ccbca896,
title = "Challenges and recent progress in drug discovery for tropical diseases",
abstract = "Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.",
author = "{De Rycker}, Manu and Beatriz Baraga{\~n}a and Duce, {Suzanne L.} and Gilbert, {Ian H.}",
note = "We acknowledge the following organizations that have supported our drug-discovery efforts for some of these diseases: Wellcome Trust, Medicines for Malaria Venture, the Bill and Melinda Gates Foundation and Drugs for Neglected Diseases initiative. We thank members of the Drug Discovery Unit for helpful discussions and K. Read, S. Green and S. Wyllie for reading the manuscript.",
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T1 - Challenges and recent progress in drug discovery for tropical diseases

AU - De Rycker, Manu

AU - Baragaña, Beatriz

AU - Duce, Suzanne L.

AU - Gilbert, Ian H.

N1 - We acknowledge the following organizations that have supported our drug-discovery efforts for some of these diseases: Wellcome Trust, Medicines for Malaria Venture, the Bill and Melinda Gates Foundation and Drugs for Neglected Diseases initiative. We thank members of the Drug Discovery Unit for helpful discussions and K. Read, S. Green and S. Wyllie for reading the manuscript.

PY - 2018/7/25

Y1 - 2018/7/25

N2 - Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.

AB - Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.

U2 - 10.1038/s41586-018-0327-4

DO - 10.1038/s41586-018-0327-4

M3 - Review article

C2 - 30046073

AN - SCOPUS:85050680571

VL - 559

SP - 498

EP - 506

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7715

ER -