Challenges of treating asthma in people who smoke

Mark Spears (Lead / Corresponding author), Euan Cameron, Rekha Chaudhuri, Neil C. Thomson

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


Cigarette smoking is common in asthma and is associated with poor symptom control and a reduced therapeutic response to inhaled and oral corticosteroids as compared with nonsmokers with asthma. This review examines the range of adverse health effects of smoking in asthma, the inflammatory mechanisms that may influence the efficacy of current drugs and discusses potential future therapeutic directions.

Original languageEnglish
Pages (from-to)257-268
Number of pages12
JournalExpert Review of Clinical Immunology
Issue number2
Publication statusPublished - Mar 2010


  • Airway inflammation
  • Asthma
  • Combination therapy
  • Corticosteroid
  • Corticosteroid insensitivity
  • Leukotriene-receptor antagonist
  • Smoker
  • Smoking cessation
  • Theophylline

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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