Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Scott Palmer; Karina Litvinova; Andrey Dunaev; Stewart Fleming; David McGloin; Ghulam Nabi

doi:10.1364/BOE.7.001193

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Scott Palmer, Karina Litvinova, Andrey Dunaev, Stewart Fleming, David McGloin, Ghulam Nabi (Lead / Corresponding author)

Physics

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Abstract

Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to
muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients

Original language	English
Pages (from-to)	1193-2000
Number of pages	8
Journal	Biomedical Optics Express
Volume	7
Issue number	4
DOIs	https://doi.org/10.1364/BOE.7.001193
Publication status	Published - 7 Mar 2016

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Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
Final published version, 1.33 MBLicence: CC BY

https://www.osapublishing.org/boe/abstract.cfm?uri=boe-7-4-1193&origin=search

Development of non-invasive techniques for bladder cancer diagnosis and therapy
Palmer, S. G. (Author), Nabi, G. (Supervisor) & McGloin, D. (Supervisor), 2016
Student thesis: Doctoral Thesis › Doctor of Philosophy

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Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer
Palmer, S. (Creator), Litvinova, K. (Contributor), Dunaev, A. (Contributor), Fleming, S. (Contributor), McGloin, D. (Contributor) & Nabi, G. (Contributor), University of Dundee, 30 Jun 2016
DOI: 10.15132/10000108, https://www.osapublishing.org/boe/abstract.cfm?uri=boe-7-4-1193
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Nabi, Ghulam
- Cancer Research - Clinical Professor (Teaching and Research) of Surgical Uro-Oncology
Person: Academic

Cite this

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title = "Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer",

abstract = "Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells tomuscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients",

author = "Scott Palmer and Karina Litvinova and Andrey Dunaev and Stewart Fleming and David McGloin and Ghulam Nabi",

note = "This work was funded through the European Union seventh framework programme (EU FP7) project ABLADE (Advanced bladder cancer laser diagnostics and therapy) (grant agreement number 324370) with studentship contributions from the NHS and EPSRC (grant number EP/K503010/1) and partially by the state task of the Ministry of Education and Science, Russian Federation, for the State University – Education-Science-Production Complex (basic part, №310).",

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AU - Nabi, Ghulam

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AB - Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells tomuscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients

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Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Abstract

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Student theses

Development of non-invasive techniques for bladder cancer diagnosis and therapy

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Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Profiles

Nabi, Ghulam

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