Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Scott Palmer, Karina Litvinova, Andrey Dunaev, Stewart Fleming, David McGloin, Ghulam Nabi (Lead / Corresponding author)

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Abstract

Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to
muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients
Original languageEnglish
Pages (from-to)1193-2000
Number of pages8
JournalBiomedical Optics Express
Volume7
Issue number4
DOIs
Publication statusPublished - 7 Mar 2016

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