Changes in prevalence of faecal occult blood positivity over time

Anna Goulding, Gavin R. C. Clark, Annie S. Anderson, Judith A. Strachan, Callum G. Fraser, Robert J. C. Steele (Lead / Corresponding author)

Research output: Contribution to journalArticle

19 Downloads (Pure)

Abstract

Objectives: Changes in the prevalence of faecal occult blood test positivity over time have not been previously reported, but could have important implications. This study examined the positivity of the initial guaiac faecal occult blood test, a surrogate marker for colorectal bleeding, in participants aged 50 in a national bowel screening programme.

Methods: Data from the Scottish Bowel Screening Programme were used to study the initial positivity of the guaiac faecal occult blood test between 2007 and 2017. Positive predictive values of the testing process for colorectal cancer and adenoma were assessed over the same time period.

Results: Across Scotland, the initial guaiac faecal occult blood test positivity increased from 4.1 to 10.8%. In NHS Grampian and NHS Fife, two of the three NHS Boards which began roll-out of screening in 2007, it increased from 4.0 to 10.9%. In the Scottish Bowel Screening Programme, the positive predictive value declined from 11.0 to 6.6% for colorectal cancer and increased from 31.6 to 39.8% for adenoma.

Conclusions: In the Scottish programme over a decade, initial guaiac faecal occult blood test positivity increased in participants aged 50. This may be associated with changes in lifestyle and might have implications for screening clinical outcomes, including positive predictive value.
Original languageEnglish
JournalJournal of Medical Screening
Early online date31 Jul 2019
DOIs
Publication statusE-pub ahead of print - 31 Jul 2019

Fingerprint

Occult Blood
Guaiac
Hematologic Tests
Adenoma
Colorectal Neoplasms
Scotland
Life Style
Biomarkers
Hemorrhage

Keywords

  • Adenoma
  • colorectal cancer
  • faecal immunochemical test
  • faecal occult blood test
  • screening

Cite this

@article{05fda8cd96514555bb35004ad98e934a,
title = "Changes in prevalence of faecal occult blood positivity over time",
abstract = "Objectives: Changes in the prevalence of faecal occult blood test positivity over time have not been previously reported, but could have important implications. This study examined the positivity of the initial guaiac faecal occult blood test, a surrogate marker for colorectal bleeding, in participants aged 50 in a national bowel screening programme.Methods: Data from the Scottish Bowel Screening Programme were used to study the initial positivity of the guaiac faecal occult blood test between 2007 and 2017. Positive predictive values of the testing process for colorectal cancer and adenoma were assessed over the same time period.Results: Across Scotland, the initial guaiac faecal occult blood test positivity increased from 4.1 to 10.8{\%}. In NHS Grampian and NHS Fife, two of the three NHS Boards which began roll-out of screening in 2007, it increased from 4.0 to 10.9{\%}. In the Scottish Bowel Screening Programme, the positive predictive value declined from 11.0 to 6.6{\%} for colorectal cancer and increased from 31.6 to 39.8{\%} for adenoma.Conclusions: In the Scottish programme over a decade, initial guaiac faecal occult blood test positivity increased in participants aged 50. This may be associated with changes in lifestyle and might have implications for screening clinical outcomes, including positive predictive value.",
keywords = "Adenoma, colorectal cancer, faecal immunochemical test, faecal occult blood test, screening",
author = "Anna Goulding and Clark, {Gavin R. C.} and Anderson, {Annie S.} and Strachan, {Judith A.} and Fraser, {Callum G.} and Steele, {Robert J. C.}",
year = "2019",
month = "7",
day = "31",
doi = "10.1177/0969141319866880",
language = "English",
journal = "Journal of Medical Screening",
issn = "0969-1413",
publisher = "SAGE Publications",

}

Changes in prevalence of faecal occult blood positivity over time. / Goulding, Anna; Clark, Gavin R. C.; Anderson, Annie S.; Strachan, Judith A.; Fraser, Callum G.; Steele, Robert J. C. (Lead / Corresponding author).

In: Journal of Medical Screening, 31.07.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in prevalence of faecal occult blood positivity over time

AU - Goulding, Anna

AU - Clark, Gavin R. C.

AU - Anderson, Annie S.

AU - Strachan, Judith A.

AU - Fraser, Callum G.

AU - Steele, Robert J. C.

PY - 2019/7/31

Y1 - 2019/7/31

N2 - Objectives: Changes in the prevalence of faecal occult blood test positivity over time have not been previously reported, but could have important implications. This study examined the positivity of the initial guaiac faecal occult blood test, a surrogate marker for colorectal bleeding, in participants aged 50 in a national bowel screening programme.Methods: Data from the Scottish Bowel Screening Programme were used to study the initial positivity of the guaiac faecal occult blood test between 2007 and 2017. Positive predictive values of the testing process for colorectal cancer and adenoma were assessed over the same time period.Results: Across Scotland, the initial guaiac faecal occult blood test positivity increased from 4.1 to 10.8%. In NHS Grampian and NHS Fife, two of the three NHS Boards which began roll-out of screening in 2007, it increased from 4.0 to 10.9%. In the Scottish Bowel Screening Programme, the positive predictive value declined from 11.0 to 6.6% for colorectal cancer and increased from 31.6 to 39.8% for adenoma.Conclusions: In the Scottish programme over a decade, initial guaiac faecal occult blood test positivity increased in participants aged 50. This may be associated with changes in lifestyle and might have implications for screening clinical outcomes, including positive predictive value.

AB - Objectives: Changes in the prevalence of faecal occult blood test positivity over time have not been previously reported, but could have important implications. This study examined the positivity of the initial guaiac faecal occult blood test, a surrogate marker for colorectal bleeding, in participants aged 50 in a national bowel screening programme.Methods: Data from the Scottish Bowel Screening Programme were used to study the initial positivity of the guaiac faecal occult blood test between 2007 and 2017. Positive predictive values of the testing process for colorectal cancer and adenoma were assessed over the same time period.Results: Across Scotland, the initial guaiac faecal occult blood test positivity increased from 4.1 to 10.8%. In NHS Grampian and NHS Fife, two of the three NHS Boards which began roll-out of screening in 2007, it increased from 4.0 to 10.9%. In the Scottish Bowel Screening Programme, the positive predictive value declined from 11.0 to 6.6% for colorectal cancer and increased from 31.6 to 39.8% for adenoma.Conclusions: In the Scottish programme over a decade, initial guaiac faecal occult blood test positivity increased in participants aged 50. This may be associated with changes in lifestyle and might have implications for screening clinical outcomes, including positive predictive value.

KW - Adenoma

KW - colorectal cancer

KW - faecal immunochemical test

KW - faecal occult blood test

KW - screening

UR - http://www.scopus.com/inward/record.url?scp=85070391860&partnerID=8YFLogxK

U2 - 10.1177/0969141319866880

DO - 10.1177/0969141319866880

M3 - Article

C2 - 31364470

JO - Journal of Medical Screening

JF - Journal of Medical Screening

SN - 0969-1413

ER -