Changes in RT‐PCR test results and symptoms during the menstrual cycle of female individuals infected with SARS‐CoV‐2: report of two cases

Hua Zheng, Juan Tan (Lead / Corresponding author), Ke Ma, Weihua Meng

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
63 Downloads (Pure)

Abstract

The implications of the menstrual cycle for disease susceptibility, development, and severity of acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection are largely unknown. Here, we describe two women infected with SARS‐CoV‐2 whose real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) test results and symptoms changed during the menstrual cycle. The first patient developed a fever on the first day of her menstrual period, and again on the first day of her next menstrual period after hospital discharge. RT‐PCR test results were positive during the first menstrual period before admission, but turned negative during hospitalization, and then were positive again during the second menstrual period after hospital discharge. Another one also developed a fever again on the first day of her menstrual period after hospital discharge. RT‐PCR test results were negative before admission and during hospitalization, but turned positive during the first menstrual period after hospital discharge. The cases indicate sex hormones may play an important role in SARS‐CoV‐2 infection. For women with history of exposure to SARS‐CoV‐2, the management protocol should include assessment of the menstrual status.
Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalJournal of Medical Virology
Volume93
Issue number1
Early online date8 Jul 2020
DOIs
Publication statusPublished - Jan 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • fever
  • menstrual cycle

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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