Abstract
Prostate cancer has a poor prognosis and high mortality rate due to metastases. Extracellular matrix (ECM) re‐modelling and stroma composition have been linked to cancer progression, including key components of cell migration, tumour metastasis, and tissue modulus. Moreover, collagens are one of the most significant components of the extracellular matrix and have been ascribed to many aspects of neoplastic transformation. This study characterises collagen remodelling around localised prostate cancer using the second harmonic generation of collagen (SHG), genotyping and ultrasound shear wave elastography (USWE) measured modulus in men with clinically localised prostate cancer. Tempo‐sequence assay for gene expression of COL1A1 and COL3A1 was used to confirm the expression of collagen. Second‐harmonic generation imaging and genotyping of ECM around prostate cancer showed changes in content, orientation, and type of collagen according to Gleason grades (cancer aggressivity), and this correlated with the tissue modulus measured by USWE in kilopascals. Furthermore, there were clear differences between collagen orientation and type around normal and cancer tissues.
| Original language | English |
|---|---|
| Article number | 5553 |
| Number of pages | 14 |
| Journal | Cancers |
| Volume | 13 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 5 Nov 2021 |
Keywords
- prostate
- collagen
- second-generation harmonics
- shear wave
- elastography
- ultrasound
- Second‐generation harmonics
- Collagen
- Shear wave
- Elastography
- Prostate
- Ultrasound
ASJC Scopus subject areas
- Oncology
- Cancer Research
