Characterisation of prostate lesions using transrectal shear wave elastography (SWE) ultrasound imaging: a systematic review

Thineskrishna Anbarasan (Lead / Corresponding author), Cheng Wei, Jeffrey C. Bamber, Richard G. Barr, Ghulam Nabi

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Abstract

Background: Ultrasound based shear wave elastography (SWE) can non-invasively assess prostate tissue stiffness. This systematic review aims to evaluate SWE for the detection of prostate cancer (PCa) and compare diagnostic estimates between studies reporting detection of all PCa and clinically significant PCa (csPCa).

Methods: A literature search was performed using the MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov and CINAHL databases. Studies evaluating SWE for the detection of PCa using histopathology as reference standard were included.

Results: Sixteen studies including 2,277 patients were included for review. Nine studies evaluated SWE for the detection of PCa using systematic biopsy as reference standard at per-sample-level, with a pooled sensitivity and specificity of 0.85 (95% CI 0.74-0.92) and 0.85 (95% CI 0.75-0.91) respectively. Five studies evaluated SWE for the detection of PCa using histopathology of radical prostatectomy (RP) specimen as the reference standard, with a pooled sensitivity and specificity of 0.71 (95% CI 0.55-0.83) and 0.74 (95% CI 0.42-0.92) respectively. Sub-group analysis revealed a higher pooled sensitivity (0.77 vs 0.62) and specificity (0.84 vs 0.53) for detection of csPCa compared to all PCa, amongst studies using RP specimen as the reference standard.

Conclusion: SWE is an attractive imaging modality for the detection of PCa.
Original languageEnglish
Article number122
Number of pages15
JournalCancers
Volume13
Issue number1
DOIs
Publication statusPublished - 2 Jan 2021

Keywords

  • prostate cancer
  • shear wave elastography
  • ultrasound

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