Characteristics and outcomes of over 300,000 COVID-19 individuals with history of cancer in the United States and Spain

Elena Roel, Andrea Pistillo, Martina Recalde, Anthony G. Sena, Sergio Fernandez-Bertolin, Maria Aragon, Diana Puente, Waheed-Ul-Rahman Ahmed, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Carlos Areia, Clair Blacketer, William Carter, Paula Casajust, Aedín C. Culhane, Dalia Dawoud, Frank DeFalco, Scott L. DuVall, Thomas FalconerAsieh Golozar, Mengchun Gong, Laura Hester, George Hripcsak, Eng Hooi Tan, Hokyun Jeon, Jitendra Jonnagaddala, Lana Yh Lai, Kristine E. Lynch, Michael E. Matheny, Daniel R. Morales, Karthik Natarajan, Fredrik Nyberg, Anna Ostropolets, Jose D. Posada, Albert Prats-Uribe, Christian G. Reich, Donna R. Rivera, Lisa M. Schilling, Isabelle Soerjomataram, Karishma Shah, Nigam H. Shah, Yang Shen, Matthew Spotnitz, Vignesh Subbian, Marc A. Suchard, Annalisa Trama, Lin Zhang, Ying Zhang, Patrick B. Ryan, Daniel Prieto-Alhambra, Kristin Kostka, Talita Duarte-Salles

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Abstract

Background: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and COVID-19. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.

Methods: We conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: i) diagnosed with COVID-19, ii) hospitalized with COVID-19, and iii) hospitalized with influenza in 2017-2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.

Results: We included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5-19% and 1-14% in the diagnosed cohort, respectively). Hematological malignancies were also frequent, with non-Hodgkin's lymphoma being among the 5 most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n=67,743) had a similar distribution of cancer subtypes, sex, age and comorbidities but lower occurrence of adverse events.

Conclusions: Patients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematological malignancies were frequent.

Impact: This study provides epidemiologic characteristics that can inform clinical care and etiological studies.

Original languageEnglish
JournalCancer Epidemiology, Biomarkers and Prevention
Early online date16 Jul 2021
DOIs
Publication statusE-pub ahead of print - 16 Jul 2021

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