TY - JOUR
T1 - Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19
AU - Daines, Luke
AU - Zheng, Bang
AU - Elneima, Omer
AU - Harrison, Ewen
AU - Lone, Nazir I.
AU - Hurst, John R.
AU - Brown, Jeremy S.
AU - Sapey, Elizabeth
AU - Chalmers, James D.
AU - Quint, Jennifer K.
AU - Pfeffer, Paul
AU - Siddiqui, Salman
AU - Walker, Samantha
AU - Poinasamy, Krisnah
AU - McAuley, Hamish
AU - Sereno, Marco
AU - Shikotra, Aarti
AU - Singapuri, Amisha
AU - Docherty, Annemarie B.
AU - Marks, Michael
AU - Toshner, Mark
AU - Howard, Luke S.
AU - Horsley, Alex
AU - Jenkins, Gisli
AU - Porter, Joanna C.
AU - Ho, Ling-Pei
AU - Raman, Betty
AU - Wain, Louise V.
AU - Brightling, Christopher E.
AU - Evans, Rachael A.
AU - Heaney, Liam G.
AU - De Soyza, Anthony
AU - Sheikh, Aziz
AU - PHOSP-COVID Collaborative Group
AU - George, J
N1 - Funding Information:
PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 (grant references MR/V027859/1 and COV0319). Core funding was provided by NIHR Leicester Biomedical Research Centre to support the PHOSP-COVID coordination team and NIHR Biomedical Research Centres, Clinical Research Facilities and NIHR Health Protection Research Unit, and Translational Research Collaborations networks across the country. The study was also supported by the UK Health Data Research BREATHE Hub. Funding information for this article has been deposited with the Crossref Funder Registry.
Copyright:
©The authors 2023.
PY - 2023/2/20
Y1 - 2023/2/20
N2 - Background: Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation.Methods: PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0-10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness.Results: We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14-2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06-2.35), female sex (adjusted OR 1.56, 95% CI 1.21-2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00-1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35-0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14-0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63-0.69) and good calibration (calibration slope 1.00, 95% CI 0.80-1.21).Conclusions: Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.
AB - Background: Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation.Methods: PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0-10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness.Results: We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14-2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06-2.35), female sex (adjusted OR 1.56, 95% CI 1.21-2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00-1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35-0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14-0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63-0.69) and good calibration (calibration slope 1.00, 95% CI 0.80-1.21).Conclusions: Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.
UR - http://www.scopus.com/inward/record.url?scp=85148888546&partnerID=8YFLogxK
U2 - 10.1183/23120541.00274-2022
DO - 10.1183/23120541.00274-2022
M3 - Article
C2 - 36820079
SN - 2312-0541
VL - 9
JO - ERJ Open Research
JF - ERJ Open Research
IS - 1
M1 - 00274-2022
ER -