Characteristics of 5-aminolaevulinic acid-induced protoporphyrin IX fluorescence in human skin in vivo

S. H. Ibbotson, C. Jong, A. Lesar, J. S. Ferguson, M. Padgett, M. O'Dwyer, R. Barnetson, J. Ferguson

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Topical photodynamic therapy (PDT) is increasingly being used to treat skin cancers. Knowledge of the detailed characteristics of 5-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence in diseased and normal skin is incomplete. Understanding the characteristics of PpIX fluorescence in normal skin may facilitate optimization of PDT regimes while minimizing side effects in the surrounding normal skin. We investigated the characteristics of ALA-induced PpIX fluorescence in normal skin.
    Original languageEnglish
    Pages (from-to)105-110
    Number of pages6
    JournalPhotodermatology, Photoimmunology & Photomedicine
    Volume22
    Issue number2
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Reference Values
    • Skin
    • Fluorescence
    • Humans
    • Adult
    • Middle Aged
    • Protoporphyrins
    • Male
    • Female
    • Aminolevulinic Acid

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