Characteristics of outcome in schizophrenia at 13 years

Peter Mason; Glynn Harrison; Cristine Glazebrook; Ian Medley; Tim Dalkin; Tim Croudace

doi:10.1192/bjp.167.5.596

Characteristics of outcome in schizophrenia at 13 years

Peter Mason (Lead / Corresponding author)
, Glynn Harrison
, Cristine Glazebrook
, Ian Medley
, Tim Dalkin
, Tim Croudace

Research output: Contribution to journal › Article › peer-review

125 Citations (Scopus)

Abstract

BACKGROUND This paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia.

METHOD In a 13-year follow-up study of a cohort identified in Nottingham in 1978-80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments.

RESULTS Four of the original 67 patients with ICD-9 schizophrenia were lost to follow-up and five were dead: 52% were without psychotic symptoms in the last two years of follow-up, 52% were without negative symptoms and 55% showed good/fair social functioning. However, only 17% were alive at follow-up, without symptoms and disability, and receiving no treatment.

CONCLUSIONS The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.

Original language	English
Pages (from-to)	596-603
Number of pages	8
Journal	British Journal of Psychiatry
Volume	167
Issue number	5
DOIs	https://doi.org/10.1192/bjp.167.5.596
Publication status	Published - Nov 1995

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10.1192/bjp.167.5.596

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title = "Characteristics of outcome in schizophrenia at 13 years",

abstract = "BACKGROUND This paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia. METHOD In a 13-year follow-up study of a cohort identified in Nottingham in 1978-80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments. RESULTS Four of the original 67 patients with ICD-9 schizophrenia were lost to follow-up and five were dead: 52\% were without psychotic symptoms in the last two years of follow-up, 52\% were without negative symptoms and 55\% showed good/fair social functioning. However, only 17\% were alive at follow-up, without symptoms and disability, and receiving no treatment. CONCLUSIONS The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.",

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AU - Mason, Peter

AU - Harrison, Glynn

AU - Glazebrook, Cristine

AU - Medley, Ian

AU - Dalkin, Tim

AU - Croudace, Tim

N1 - M1 - Article

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N2 - BACKGROUND This paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia. METHOD In a 13-year follow-up study of a cohort identified in Nottingham in 1978-80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments. RESULTS Four of the original 67 patients with ICD-9 schizophrenia were lost to follow-up and five were dead: 52% were without psychotic symptoms in the last two years of follow-up, 52% were without negative symptoms and 55% showed good/fair social functioning. However, only 17% were alive at follow-up, without symptoms and disability, and receiving no treatment. CONCLUSIONS The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.

AB - BACKGROUND This paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia. METHOD In a 13-year follow-up study of a cohort identified in Nottingham in 1978-80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments. RESULTS Four of the original 67 patients with ICD-9 schizophrenia were lost to follow-up and five were dead: 52% were without psychotic symptoms in the last two years of follow-up, 52% were without negative symptoms and 55% showed good/fair social functioning. However, only 17% were alive at follow-up, without symptoms and disability, and receiving no treatment. CONCLUSIONS The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.

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JO - British Journal of Psychiatry

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Characteristics of outcome in schizophrenia at 13 years

Abstract

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