Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis

Keyphrases

• Human African Trypanosomiasis 100%
• Nitroheterocycles 100%
• Melamine 66%
• Further Development 33%
• Physicochemical Properties 33%
• Rhodesiense 33%
• Melarsoprol 33%
• Trypanosoma Brucei 33%
• Trypanocidal Activity 33%
• Rodent Models 33%
• Infection Model 33%
• DNA Damage 33%
• In Vitro Assay 33%
• Mouse Model 33%
• Genotoxicity 33%
• Central Nervous System 33%
• Oxidative Damage 33%
• Pharmacokinetic Properties 33%
• Oral Route 33%
• Drug Candidates 33%
• Chromosome-level 33%
• Base-pair Substitution 33%
• Biopharmaceutical Properties 33%
• Comet Test 33%
• Nitroarene Reduction 33%
• DNA Comets 33%
• Toxicity Potential 33%
• Ames Test 33%
• Micronucleus Test 33%

Pharmacology, Toxicology and Pharmaceutical Science

• African Trypanosomiasis 100%
• Melamine 66%
• Base 33%
• Melarsoprol 33%
• Trypanosoma Brucei 33%
• Infection 33%
• Mouse Model 33%
• Nitroreductase 33%
• Genotoxicity 33%
• Pharmacokinetics 33%
• Ames Test 33%