Characterization of bronchiectasis in the elderly

Giuseppe Bellelli, James D. Chalmers, Giovanni Sotgiu, Simone Dore, Melissa J. McDonnell, Pieter C. Goeminne, Katerina Dimakou, Dusan Skrbic, Andrea Lombi, Federico Pane, Dusanka Obradovic, Thomas C. Fardon, Robert M. Rutherford, Alberto Pesci, Stefano Aliberti (Lead / Corresponding author)

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Abstract

Introduction Although bronchiectasis particularly affects people ≥65 years of age, data describing clinical characteristics of the disease in this population are lacking. This study aimed at evaluating bronchiectasis features in older adults and elderly, along with their clinical outcomes. 

Methods This was a secondary analysis of six European databases of prospectively enrolled adult outpatients with bronchiectasis. Bronchiectasis characteristics were compared across three study groups: younger adults (18–65 years), older adults (66–75 years), and elderly (and ≥76 years). 3-year mortality was the primary study outcome. 

Results Among 1258 patients enrolled (median age: 66 years; 42.5% males), 50.9% were ≥65 years and 19.1 ≥ 75 years old. Elderly patients were more comorbid, had worse quality of life and died more frequently than the others. Differences were detected among the three study groups with regard to neither the etiology nor the severity of bronchiectasis, nor the prevalence of chronic infection with P. aeruginosa. In multivariate regression model, age (OR: 1.05; p-value: 1 (OR: 1.02; p-value: 0.001) were independent predictors of 3-year mortality, after adjustment for covariates. 

Conclusion Bronchiectasis does not substantially differ across age groups. Poor outcomes in elderly patients with bronchiectasis might be directly related to individual's frailty that should be further investigated in clinical studies.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalRespiratory Medicine
Volume119
Early online date17 Aug 2016
DOIs
Publication statusPublished - Oct 2016

Keywords

  • Comorbidity
  • COPD
  • Cystic fibrosis
  • Frailty
  • Pseudomonas

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