Characterization of cancer-induced bone pain: An exploratory study

Barry J. A. Laird (Lead / Corresponding author), John Walley, Gordon D. Murray, Eleanor Clausen, Lesley A. Colvin, Marie T. Fallon

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: Cancer-induced bone pain (CIBP) is the commonest cause of pain in patients with cancer. Its association with increased morbidity combined with limitations of currently available therapies makes it a clinical challenge. Clinical characterization of this complex pain syndrome is essential in underpinning clinical management and informing future research. The aim of this exploratory study was to characterise CIBP using self-rating scales.

Patients and methods: A cross-sectional survey of patients with CIBP was carried out in a regional oncology centre. Patients described their pain over the preceding 24 h using the McGill Pain Questionnaire, Brief Pain Inventory (BPI), and a breakthrough pain questionnaire. Multiple linear regression analyses were conducted.

Results: Fifty-five patients were recruited. Annoying, gnawing, aching, and nagging were the most commonly used words to describe CIBP. From the BPI, median average pain was 4/10 and worst pain was 7/10 on a 0-10 Numerical Rating Scale. The worst pain score correlated more strongly with BPI interference score (p=0.001). Forty-one patients had breakthrough pain. Patients with breakthrough pain had higher total BPI interference scores than those with no breakthrough pain; median (IQR); 35.0 (2.5-44.7) vs. 18.5 (5.5-26.7), p<0.01. Of the patients, 20/41 (48%) had breakthrough pain of rapid onset (less than 5 min) and short duration (less than 15 min).

Conclusion: In CIBP, worst pain most accurately reflects the characteristics of pain flares and functional impairment. Breakthrough pain is often unpredictable, sudden onset and short duration. Further characterization studies of CIBP in the broader cancer population are needed.

Original languageEnglish
Pages (from-to)1393-1401
Number of pages9
JournalSupportive Care in Cancer
Volume19
Issue number9
Early online date1 Aug 2010
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Breakthrough pain
  • Brief Pain Inventory
  • Cancer
  • Cancer-induced bone pain
  • Characterisation study
  • McGill Pain Questionnaire

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    Laird, B. J. A., Walley, J., Murray, G. D., Clausen, E., Colvin, L. A., & Fallon, M. T. (2011). Characterization of cancer-induced bone pain: An exploratory study. Supportive Care in Cancer, 19(9), 1393-1401. https://doi.org/10.1007/s00520-010-0961-3