Characterization of human pineal gland proteome

Soujanya D. Yelamanchi, Manish Kumar, Anil K. Madugundu, Lathika Gopalakrishnan, Gourav Dey, Sandip Chavan, Gajanan Sathe, Premendu P. Mathur, Harsha Gowda, Anita Mahadevan, Susarla K. Shankar, T. S.Keshava Prasad

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The pineal gland is a neuroendocrine gland located at the center of the brain. It is known to regulate various physiological functions in the body through secretion of the neurohormone melatonin. Comprehensive characterization of the human pineal gland proteome has not been undertaken to date. We employed a high-resolution mass spectrometry-based approach to characterize the proteome of the human pineal gland. A total of 5874 proteins were identified from the human pineal gland in this study. Of these, 5820 proteins were identified from the human pineal gland for the first time. Interestingly, 1136 proteins from the human pineal gland were found to contain a signal peptide domain, which indicates the secretory nature of these proteins. An unbiased global proteomic profile of this biomedically important organ should benefit molecular research to unravel the role of the pineal gland in neuropsychiatric and neurodegenerative diseases.

Original languageEnglish
Pages (from-to)3622-3632
Number of pages11
JournalMolecular BioSystems
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016

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