@article{0bca99625772443dbfc83c745b223673,
title = "Characterization of human pineal gland proteome",
abstract = "The pineal gland is a neuroendocrine gland located at the center of the brain. It is known to regulate various physiological functions in the body through secretion of the neurohormone melatonin. Comprehensive characterization of the human pineal gland proteome has not been undertaken to date. We employed a high-resolution mass spectrometry-based approach to characterize the proteome of the human pineal gland. A total of 5874 proteins were identified from the human pineal gland in this study. Of these, 5820 proteins were identified from the human pineal gland for the first time. Interestingly, 1136 proteins from the human pineal gland were found to contain a signal peptide domain, which indicates the secretory nature of these proteins. An unbiased global proteomic profile of this biomedically important organ should benefit molecular research to unravel the role of the pineal gland in neuropsychiatric and neurodegenerative diseases.",
author = "Yelamanchi, {Soujanya D.} and Manish Kumar and Madugundu, {Anil K.} and Lathika Gopalakrishnan and Gourav Dey and Sandip Chavan and Gajanan Sathe and Mathur, {Premendu P.} and Harsha Gowda and Anita Mahadevan and Shankar, {Susarla K.} and Prasad, {T. S.Keshava}",
note = "Funding Information: We thank Ministry of Health and Family Welfare, Government of India for support with the Orbitrap Fusion Tribrid instrument at NIMHANS-IOB Proteomic and Bioinformatics laboratory. We thank the Indo-US Science and Technology Forum for funding the ?Indo-US Center for Clinical and Translational Neuroscience?. The study was supported by a research grant ?DBT Programme Support on Neuroproteomics of Neurological Disorders? to IOB and NIMHANS by Department of Biotechnology (DBT), Government of India (BT/01/COE/08/05). Human brain tissues for the study were obtained from Human Brain Tissue Repository, a National Research Facility, Department of Neuropathology, NIMHANS, Bangalore, India. This publication was partly supported by a sub-award from The Johns Hopkins University, with funds provided from National Institute of Neurological Disorders and Stroke (NINDS) (Grant Number: 1RO1NS055628-01A2). The contents of the study are solely the responsibility of the authors and do not represent the official view of NINDS or JHU or NIMHANS. We thank Thermo Scientific for providing access to instrumentation and software. Soujanya D. Yelamanchi is a recipient of a DST-INSPIRE Senior Research Fellowship from Department of Science and Technology (DST), Government of India. Manish Kumar and Gajanan Sathe are recipients of Senior Research Fellowships from CSIR and Anil K. Madugundu is a recipient of a BINC-Senior Research Fellowship from DBT. Lathika Gopalakrishnan is a recipient of a DST-INSPIRE Junior Research Fellowship from DST. Gourav Dey is a recipient of a Senior Research Fellowship from UGC, Government of India. Harsha Gowda is a Wellcome Trust/DBT India Alliance Early Career Fellow. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",
year = "2016",
month = dec,
day = "1",
doi = "10.1039/c6mb00507a",
language = "English",
pages = "3622--3632",
journal = "Molecular BioSystems",
issn = "1742-206X",
publisher = "Royal Society of Chemistry",
number = "12",
}