Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Biochemistry, Genetics and Molecular Biology

• Ribosomal S6 Kinase 100%
• Mechanistic Target of Rapamycin 66%
• Signal Transduction 33%
• Growth Factor 33%
• Phosphoinositide 3-Kinase 33%
• Phosphotransferase 33%
• Kinase 33%
• Isoform 33%
• Insulin-Like Growth Factor 1 33%
• Insulin Resistance 33%
• Protein Biosynthesis 33%
• IC50 33%
• Mammalian Target of Rapamycin Complex 1 33%

Keyphrases

• S6 Kinase 1 (S6K1) 100%
• Specific Inhibitor 100%
• PF-4708671 100%
• Phosphorylation 25%
• Growth Factors 16%
• Mammalian Target of Rapamycin (mTOR) 16%
• Cancer Treatment 8%
• K(I) 8%
• Phosphoinositide 3-kinase (PI3K) 8%
• Insulin 8%
• T-loop 8%
• Insulin-like 8%
• Mitogen 8%
• Insulin Resistance 8%
• Protein Synthesis 8%
• Cell Permeable 8%
• IC50 8%
• Cancer Resistance 8%
• Hydrophobic Motif 8%
• Mammalian Target of Rapamycin Signaling Pathway 8%
• S6K1 Isoforms 8%