Characterization of sonicated breath films by Atomic Force Microscopy

Timur Saliev, M. J. Mullan, Y. Cui, Paul Campbell

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Porous structures offer a vast range of important industrial applications. In the context of medicine, and specifically in the area of controlled drug delivery, spatial [and temporal] control over local porosity has a significant influence on. net molecular flux through [membrane-based] controlled release platforms. Such systems may be formulated as oral, transdermal, or even implantable entities, and address chronic infusion needs covering such ailments as diabetes, cancer and hypertension. In all the aforementioned situations, a facility to spatially control porosity could offer significant advantage, such as safer controlled release over extended durations. We have previously described a novel route to engineering-in such flexibility within polymeric thin films by modifying spin-coating protocols to accommodate breath film patterning, that is, the spatially controlled condensation of pore forming droplets onto a liquid-polymer film. Here we demonstrate that those same breath film structures are acoustically responsive. We show, using AFM that the integrity of such films can be compromised to form a leaky structure through which solutions can diffuse. We advocate the use of such films as depot capping structures for controlled drug delivery.

    Original languageEnglish
    Title of host publication2008 IEEE Ultrasonics Symposium, Vols1-4 and Appendix
    Place of PublicationNEW YORK
    PublisherIEEE Computer Society
    Pages2066-2067
    Number of pages2
    ISBN (Print)978-1-4244-2428-3
    DOIs
    Publication statusPublished - 2008
    Event2008 IEEE International Ultrasonics Symposium (IUS) - Beijing, China
    Duration: 2 Nov 20085 Nov 2008
    http://ewh.ieee.org/conf/ius_2008/

    Conference

    Conference2008 IEEE International Ultrasonics Symposium (IUS)
    Abbreviated title2008 IEEE IUS
    CountryChina
    CityBeijing
    Period2/11/085/11/08
    Internet address

    Keywords

    • polymer
    • porous
    • breath figure
    • thermal imaging drug delivery

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