Characterization of the cellular action of the MSK inhibitor SB-747651A

Keyphrases

• Mitogen 100%
• Cellular Actions 100%
• S6 Kinase 1 (S6K1) 66%
• Macrophages 33%
• Protein Kinase 33%
• Ro 31-8220 33%
• Cell Properties 16%
• IC50 Value 16%
• Lipopolysaccharide 16%
• Mitogen-activated Protein Kinase 16%
• Phosphorylation 16%
• Protein Kinase 2 16%
• Extracellular Signal-regulated Kinase 1/2 16%
• CAMP Response Element-binding Protein 16%
• MSK2 16%
• Histone H3 16%
• Nuclear Proteins 16%
• P38α 16%
• Off-target Effects 16%
• Anti-inflammatory Cytokines 16%
• Inflammatory Cytokine Response 16%
• Interleukin-10 16%
• ERK1 16%
• Enhanced Selectivity 16%
• In Vivo Properties 16%
• Lipopolysaccharide Stimulation 16%
• PRK2 16%
• Double-stranded RNA-dependent Protein Kinase 16%
• Rho-associated Protein Kinase 2 16%

Neuroscience

• Kinase 100%
• In Vitro 66%
• Macrophage 33%
• Lipopolysaccharide 33%
• Mitogen Activated Protein Kinase 3 33%
• H-89 33%
• Protein Kinases 33%
• Ribosomal S6 Kinase 33%
• Cyclic Adenosine Monophosphate 16%
• Histone H3 16%
• Protein Binding 16%
• Proinflammatory Cytokine 16%
• Anti-Inflammatory 16%
• Interleukin 10 16%
• S6 Kinase 16%
• Cytokine Production 16%
• Mitogen Activated Protein Kinase 14 16%
• Protein Kinase R 16%
• Response Element 16%
• Rho-Associated Protein Kinase 16%

Biochemistry, Genetics and Molecular Biology

• Phosphotransferase 100%
• Kinase 100%
• Protein Kinases 28%
• Macrophage 28%
• Ribosomal S6 Kinase 28%
• H-89 28%
• Lipopolysaccharide 28%
• Wild Type 14%
• Cyclic Adenosine Monophosphate 14%
• Transcription 14%
• Mitogen-Activated Protein Kinase 14%
• Binding Protein 14%
• Proinflammatory Cytokine 14%
• Extracellular Signal-Regulated Kinases 14%
• Response Element 14%
• Histone H3 14%
• IC50 14%
• Inflammatory Cytokine 14%
• Cytokine Production 14%
• Interleukin 10 14%
• Rho-Associated Protein Kinase 14%
• Protein Kinase R 14%