Characterizing breast phenotype with a novel measure of fibroglandular structure

John H. Hipwell, Lewis D. Griffin, Patsy J. Whelehan, Wenlong Song, Xiying Zhang, Jan M. Lesniak, Sarah Vinnicombe, Andy Evans, Jonathan Berg, David J. Hawkes

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)


    Understanding, and accurately being able to predict, breast cancer risk would greatly enhance the early detection, and hence treatment, of the disease. In this paper we describe a new metric for mammographic structure, "orientated mammographic entropy", via a comprehensive classification of image pixels into one of seven basic image feature (BIF) classes. These classes are flat (zero order), slope-like (first order), and maximum, minimum, light-lines, dark-lines and saddles (second order). By computing a reference breast orientation with respect to breast shape and nipple location, these classes are further subdivided into 23 orientated BIF classes. For a given mammogram a histogram is constructed from the proportion of pixels in each of the 23 classes, and the orientated mammographic entropy, H , computed from this histogram. H , shows good correlation between left and right breasts (r =0.76, N=478), and is independent of both mammographic breast area, a surrogate for breast size (r =0.07, N=974), and breast density, as estimated using Volpara software (r =0.11, N=385). We illustrate this metric by examining its relationship to familial breast cancer risk, for 118 subjects, using the BOADICEA genetic susceptibility to breast and ovarian cancer model.
    Original languageEnglish
    Title of host publicationBreast Imaging
    Subtitle of host publication11th International Workshop, IWDM 2012, Philadelphia, PA, USA, July 8-11, 2012. Proceedings
    EditorsAndrew D. A. Maidment, Predrag R. Bakic, Sara Gavenonis
    Place of PublicationBerlin
    Number of pages8
    ISBN (Electronic)9783642312717
    ISBN (Print)9783642312700
    Publication statusPublished - 2012
    Event11th International Workshop on Breast Imaging - Houston Hall, University of Pennsylvania , Philadelphia, United States
    Duration: 8 Jul 201211 Jul 2012

    Publication series

    NameLecture notes in computer science


    Workshop11th International Workshop on Breast Imaging
    Abbreviated titleIWDM 2012
    Country/TerritoryUnited States
    Internet address


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