Characterizing non-tuberculous mycobacteria infection in bronchiectasis

Paola Faverio, Anna Stainer, Giulia Bonaiti, Stefano C. Zucchetti, Edoardo Simonetta, Giuseppe Lapadula, Almerico Marruchella, Andrea Gori, Francesco Blasi, Luigi Codecasa, Alberto Pesci, James D. Chalmers, Michael R. Loebinger, Stefano Aliberti (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a "tree-in-bud" pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research.

Original languageEnglish
Article number1913
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume17
Issue number11
DOIs
Publication statusPublished - 16 Nov 2016

Fingerprint

Pulmonary diseases
Mycobacterium Infections
Bronchiectasis
infectious diseases
Mycobacterium
Lung
Bacteria
History
Infection
Lung Diseases
Monitoring
isolation
Recurrence
pathogenesis
Italy
bacteria
Observational Studies
Weight Loss
indication
Therapeutics

Keywords

  • non-cystic fibrosis bronchiectasis
  • non-tuberculous mycobacteria
  • pulmonary infection

Cite this

Faverio, P., Stainer, A., Bonaiti, G., Zucchetti, S. C., Simonetta, E., Lapadula, G., ... Aliberti, S. (2016). Characterizing non-tuberculous mycobacteria infection in bronchiectasis. International Journal of Molecular Sciences, 17(11), [1913]. https://doi.org/10.3390/ijms17111913
Faverio, Paola ; Stainer, Anna ; Bonaiti, Giulia ; Zucchetti, Stefano C. ; Simonetta, Edoardo ; Lapadula, Giuseppe ; Marruchella, Almerico ; Gori, Andrea ; Blasi, Francesco ; Codecasa, Luigi ; Pesci, Alberto ; Chalmers, James D. ; Loebinger, Michael R. ; Aliberti, Stefano. / Characterizing non-tuberculous mycobacteria infection in bronchiectasis. In: International Journal of Molecular Sciences. 2016 ; Vol. 17, No. 11.
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Faverio, P, Stainer, A, Bonaiti, G, Zucchetti, SC, Simonetta, E, Lapadula, G, Marruchella, A, Gori, A, Blasi, F, Codecasa, L, Pesci, A, Chalmers, JD, Loebinger, MR & Aliberti, S 2016, 'Characterizing non-tuberculous mycobacteria infection in bronchiectasis', International Journal of Molecular Sciences, vol. 17, no. 11, 1913. https://doi.org/10.3390/ijms17111913

Characterizing non-tuberculous mycobacteria infection in bronchiectasis. / Faverio, Paola; Stainer, Anna; Bonaiti, Giulia; Zucchetti, Stefano C.; Simonetta, Edoardo; Lapadula, Giuseppe; Marruchella, Almerico; Gori, Andrea; Blasi, Francesco; Codecasa, Luigi; Pesci, Alberto; Chalmers, James D.; Loebinger, Michael R.; Aliberti, Stefano (Lead / Corresponding author).

In: International Journal of Molecular Sciences, Vol. 17, No. 11, 1913, 16.11.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characterizing non-tuberculous mycobacteria infection in bronchiectasis

AU - Faverio, Paola

AU - Stainer, Anna

AU - Bonaiti, Giulia

AU - Zucchetti, Stefano C.

AU - Simonetta, Edoardo

AU - Lapadula, Giuseppe

AU - Marruchella, Almerico

AU - Gori, Andrea

AU - Blasi, Francesco

AU - Codecasa, Luigi

AU - Pesci, Alberto

AU - Chalmers, James D.

AU - Loebinger, Michael R.

AU - Aliberti, Stefano

N1 - No funding

PY - 2016/11/16

Y1 - 2016/11/16

N2 - Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a "tree-in-bud" pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research.

AB - Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a "tree-in-bud" pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research.

KW - non-cystic fibrosis bronchiectasis

KW - non-tuberculous mycobacteria

KW - pulmonary infection

U2 - 10.3390/ijms17111913

DO - 10.3390/ijms17111913

M3 - Article

VL - 17

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 11

M1 - 1913

ER -

Faverio P, Stainer A, Bonaiti G, Zucchetti SC, Simonetta E, Lapadula G et al. Characterizing non-tuberculous mycobacteria infection in bronchiectasis. International Journal of Molecular Sciences. 2016 Nov 16;17(11). 1913. https://doi.org/10.3390/ijms17111913