Keyphrases
Double Knockout
100%
African Trypanosomes
100%
Drug Target
100%
Dihydrofolate Reductase-thymidylate Synthase
100%
Genetic Validation
100%
Virulence
33%
PTR1
33%
Trimetrexate
33%
Raltitrexed
33%
Thymidine
33%
Drug Discovery
16%
Bloodstream
16%
Escherichia Coli
16%
Cell Death
16%
Morphological Changes
16%
Potent Inhibitor
16%
T. Brucei
16%
Trypanosoma Brucei
16%
Sigma Phase
16%
Growth Arrest
16%
Trypanosome
16%
Pteridine Reductase 1
16%
Methotrexate
16%
Normal Growth
16%
Low Folate
16%
Folic Acid
16%
Promising Target
16%
Parasite Survival
16%
Knockout Cells
16%
Knockout Lines
16%
Pyrimethamine
16%
Reduced Sensitivity
16%
Biochemistry, Genetics and Molecular Biology
Genetics
100%
Trypanosoma
100%
Dihydrofolate Reductase
100%
Thymidylate Synthase
100%
Wild Type
75%
Folic Acid
50%
Trimetrexate
50%
Raltitrexed
50%
Thymidine
50%
Cell Death
25%
Morphology
25%
Transfection
25%
S Phase
25%
Escherichia coli
25%
Oxidoreductase
25%
Reductase
25%
Trypanosoma Brucei
25%
Parasite Survival
25%
Methotrexate
25%
Pyrimethamine
25%
Pharmacology, Toxicology and Pharmaceutical Science
Trypanosoma
100%
Dihydrofolate Reductase
100%
Thymidylate Synthase
100%
Folic Acid
50%
Thymidine
50%
Raltitrexed
50%
Trimetrexate
50%
Drug Discovery
25%
Escherichia coli
25%
Trypanosoma Brucei
25%
Oxidoreductase
25%
Growth Disorder
25%
Methotrexate
25%
Pteridine
25%
Pyrimethamine
25%