Chemical Validation of Trypanothione Synthetase a potential drug targer for human trypanosomiasis

Keyphrases

• T. Brucei 100%
• Trypanothione Synthetase 100%
• Glutathione 100%
• Trypanosomiasis 100%
• Potential Drugs 100%
• Spermidine 66%
• Bloodstream 33%
• Human African Trypanosomiasis 33%
• Overexpressing 33%
• Trypanosoma Brucei 33%
• Fold Increase 33%
• Trypanothione 33%
• Glutathionylspermidine 33%
• High-throughput Screening 33%
• Putative Drug Targets 33%
• Drug Target 33%
• Compound Library 33%
• EC50 33%
• Ligase 33%
• New Therapeutics 33%
• Novel Inhibitors 33%
• Knock 33%
• In Vitro Enzyme Assay 33%
• Expected Change 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Trypanothione 100%
• Glutathione 100%
• Synthetase 100%
• Trypanosomiasis 100%
• Spermidine 66%
• African Trypanosomiasis 33%
• Adenosine Triphosphate 33%
• Trypanosoma Brucei 33%
• High-Throughput Screening 33%
• Ligase 33%
• Lead Compound 33%
• Adenosine Diphosphate 33%
• EC50 33%