Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

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    30 Citations (Scopus)

    Abstract

    The isothiocyanates are among the most extensively studied chemoprotective agents. They are derived from glucosinolate precursors by the action of beta-thioglucosidase enzymes (myrosinases). The Cruciferae family represents a rich source of glucosinolates. Notably, nearly all of the biological activities of glucosinolates, in both plants and animals, are attributable to their cognate hydrolytic products, and the isothiocyanates are prominent examples. In contrast to their relatively inert glucosinolate precursors, the isothiocyanates are endowed with high chemical reactivity, especially with sulfur-centered nucleophiles, such as protein cysteine residues. There are numerous examples of the chemoprotective effects of isothiocyanates in a number of animal models of experimental carcinogenesis at various organ sites and against carcinogens of several different types. It is becoming increasingly clear that this efficient protection is due to multiple mechanisms, including induction of cytoprotective proteins through the Keap1/Nrf2/ARE pathway, inhibition of proinflammatory responses through the NF kappa B pathway, induction of cell cycle arrest and apoptosis, effects on heat shock proteins, and inhibition of angiogenesis and metastasis. Because the isothiocyanates affect the function of transcription factors and ultimately the expression of networks of genes, such protection is comprehensive and long-lasting.

    Original languageEnglish
    Title of host publicationNatural Products in Cancer Prevention and Therapy
    EditorsJohn M. Pezzuto, Nanjoo Suh
    Place of PublicationBerlin
    PublisherSpringer
    Pages179-201
    Number of pages23
    ISBN (Print)9783642345753
    DOIs
    Publication statusPublished - 2013

    Publication series

    NameTopics in Current Chemistry
    PublisherSPRINGER-VERLAG BERLIN
    Volume329
    ISSN (Print)0340-1022

    Keywords

    • NF kappa B
    • Sulforaphane
    • GLUTATHIONE S-TRANSFERASE
    • INDUCED ESOPHAGEAL TUMORIGENESIS
    • Nrf2
    • MIGRATION INHIBITORY FACTOR
    • TOBACCO-SPECIFIC NITROSAMINE
    • CELL-CYCLE ARREST
    • Glucosinolate
    • NF-KAPPA-B
    • BROCCOLI SPROUT BEVERAGES
    • Keap1
    • Phenethyl isothiocyanate
    • NQO1
    • A/J MOUSE LUNG
    • ALKYL CHAIN-LENGTH
    • DIETARY PHENETHYL ISOTHIOCYANATE

    Cite this

    Dinkova-Kostova, A. T. (2013). Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms. In J. M. Pezzuto, & N. Suh (Eds.), Natural Products in Cancer Prevention and Therapy (pp. 179-201). (Topics in Current Chemistry; Vol. 329). Springer . https://doi.org/10.1007/128_2012_337