Chicken CP49: Significant or paltry

Paul S. Wallace (Lead / Corresponding author), Susan V. Duff, Alan R. Prescott, Dennis Goebel, Harry Maisel, Roy A. Quinlan

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49ins has been identified. CP49ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalOphthalmic Research
Volume28
Issue number1
DOIs
Publication statusPublished - 1 Jan 1996

Keywords

  • CP49
  • Cytoplasmic IF
  • Intermediate filaments
  • Lamin-like
  • Lens

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