Chicken CP49: Significant or paltry

Paul S. Wallace; Susan V. Duff; Alan R. Prescott; Dennis Goebel; Harry Maisel; Roy A. Quinlan

doi:10.1159/000267945

Chicken CP49: Significant or paltry

Paul S. Wallace (Lead / Corresponding author), Susan V. Duff, Alan R. Prescott, Dennis Goebel, Harry Maisel, Roy A. Quinlan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49_ins has been identified. CP49_ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.

Original language	English
Pages (from-to)	55-57
Number of pages	3
Journal	Ophthalmic Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.1159/000267945
Publication status	Published - 1 Jan 1996

Keywords

CP49
Cytoplasmic IF
Intermediate filaments
Lamin-like
Lens

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1159/000267945

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title = "Chicken CP49: Significant or paltry",

abstract = "The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49ins has been identified. CP49ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.",

keywords = "CP49, Cytoplasmic IF, Intermediate filaments, Lamin-like, Lens",

author = "Wallace, {Paul S.} and Duff, {Susan V.} and Prescott, {Alan R.} and Dennis Goebel and Harry Maisel and Quinlan, {Roy A.}",

year = "1996",

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T2 - Significant or paltry

AU - Wallace, Paul S.

AU - Duff, Susan V.

AU - Prescott, Alan R.

AU - Goebel, Dennis

AU - Maisel, Harry

AU - Quinlan, Roy A.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49ins has been identified. CP49ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.

AB - The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49ins has been identified. CP49ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.

KW - CP49

KW - Cytoplasmic IF

KW - Intermediate filaments

KW - Lamin-like

KW - Lens

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SN - 0030-3747

VL - 28

SP - 55

EP - 57

JO - Ophthalmic Research

JF - Ophthalmic Research

IS - 1

ER -

Chicken CP49: Significant or paltry

Abstract

Keywords

ASJC Scopus subject areas

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