Chicken CP49: Significant or paltry

TY - JOUR

T1 - Chicken CP49

T2 - Significant or paltry

AU - Wallace, Paul S.

AU - Duff, Susan V.

AU - Prescott, Alan R.

AU - Goebel, Dennis

AU - Maisel, Harry

AU - Quinlan, Roy A.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49ins has been identified. CP49ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.

AB - The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been identified. Recently a unique variant of CP49, CP49ins has been identified. CP49ins contains an insertion of 49 amino acids in helix 1 b giving it characteristics similar to the lamin-like cytoplasmic IF of invertebrates. The presence of this variant form in the chick lens poses some important questions about the co-assembly of the two CP49 forms and also the evolutionary relationship with invertebrate IF proteins.

KW - CP49

KW - Cytoplasmic IF

KW - Intermediate filaments

KW - Lamin-like

KW - Lens

UR - https://www.scopus.com/pages/publications/0029870037

U2 - 10.1159/000267945

DO - 10.1159/000267945

M3 - Article

C2 - 8727966

AN - SCOPUS:0029870037

SN - 0030-3747

VL - 28

SP - 55

EP - 57

JO - Ophthalmic Research

JF - Ophthalmic Research

IS - 1

ER -