ChIP-Sequencing of TET Proteins

Kasper D. Rasmussen, Kristian Helin (Lead / Corresponding author)

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TET proteins are methylcytosine dioxygenases that interact directly with chromatin to shape the DNA methylation landscape. To increase the understanding of TET protein function in a specific cellular context, it is important to be able to map the interactions between TET proteins and DNA. This ChIP-seq protocol details our procedure to analyze TET2 bound DNA in disuccinimidyl glutarate (DSG) and formaldehyde-crosslinked chromatin but can also be adapted to study other TET enzymes.

Original languageEnglish
Title of host publicationTET Proteins and DNA Demethylation
Subtitle of host publicationMethods and Protocols
EditorsOzren Bogdanovic, Michiel Vermeulen
Place of PublicationNew York
PublisherHumana Press
Number of pages12
ISBN (Electronic)9781071612941
ISBN (Print)9781071612934 (hbk), 9781071612965 (pbk)
Publication statusPublished - 2021

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • TET1
  • TET2
  • TET3
  • DNA methylation
  • DSG
  • ChIP-seq

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology


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