Chloroquine resistance is not associated with drug metabolism in Plasmodium falciparum

B. J. Berger, J. Martiney, A. F.G. Slater, A. H. Fairlamb, A. Cerami

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    11 Citations (Scopus)

    Abstract

    Chloroquine-sensitive and -resistant clones of Plasmodium falciparum were incubated in vitro with [3H]chloroquine for 16 hr, and the resulting culture supernatants and cell pellets were analyzed by high-performance liquid chromatography for evidence of chloroquine metabolism. After separation by normal- or reverse-phase chromatography, there was no evidence of drug metabolism by the chloroquine-resistant P. falciparum. However, a single, unidentified, radiolabeled metabolite, which did not coelute with desethylchloroquine, was produced by 1 of the chloroquine-sensitive clones. Thus, chloroquine resistance does not appear to be due to drug metabolism by the resistant parasites.

    Original languageEnglish
    Pages (from-to)1004-1008
    Number of pages5
    JournalJournal of Parasitology
    Volume81
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 1995

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