Cholic acid binding by glutathione S-transferases from rat liver cytosol

J D Hayes, R C Strange, I W Percy-Robb

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Abstract

    Cholic acid-binding activity in cytosol from rat livers appears to be mainly associated with enzymes having glutathione S-transferase activity; at least four of the enzymes in this group can bind the bile acid. Examination of the subunit compositions of different glutathione S-transferases indicated that cholic acid binding and the ability to conjugate reduced glutathione with 1,2-dichloro-4-nitrobenzene may be ascribed to different subunits.

    Original languageEnglish
    Pages (from-to)83-7
    Number of pages5
    JournalBiochemical Journal
    Volume185
    Issue number1
    Publication statusPublished - 1 Jan 1980

    Keywords

    • Animals
    • Cholic Acids/metabolism
    • Chromatography, Ion Exchange
    • Cytosol/enzymology
    • Dinitrochlorobenzene/metabolism
    • Electrophoresis, Polyacrylamide Gel
    • Glutathione Transferase/isolation & purification
    • In Vitro Techniques
    • Isoenzymes/isolation & purification
    • Liver/enzymology
    • Rats

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