Chromatin as an oxygen sensor and active player in the hypoxia response

Andrew Melvin; Sonia Rocha

doi:10.1016/j.cellsig.2011.08.019

Chromatin as an oxygen sensor and active player in the hypoxia response

Andrew Melvin, Sonia Rocha

Research output: Contribution to journal › Review article › peer-review

106 Citations (Scopus)

Abstract

Changes in the availability or demand for oxygen induce dramatic changes at the cellular level. Primarily, activation of a family of oxygen labile transcription factors, Hypoxia Inducible Factor (HIF), initiates a variety of cellular processes required to re-instate oxygen homeostasis. Oxygen is sensed by molecular dioxygenases in cells, such as the prolyl-hydroxylases (PHDs), enzymes which are responsible for the oxygen-dependent regulation of HIF. As HIF is a transcription factor it must bind DNA sequences of its target genes possibly in the context of a complex chromatin structure. How chromatin structure changes in response to hypoxia is currently unknown. However, the identification of a novel class of histone demethylases as true dioxygenases suggests that chromatin can act as an oxygen sensor and plays an active role in the coordination of the cellular response to hypoxia. This review will discuss the current knowledge on how hypoxia engages with different proteins involved in chromatin organisation and dynamics. (C) 2011 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	35-43
Number of pages	9
Journal	Cellular Signalling
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.cellsig.2011.08.019
Publication status	Published - Jan 2012

Keywords

Hypoxia
Chromatin
HIF
Transcription
Chromatin remodellers
JmjC demethylases
INDUCIBLE FACTOR 1-ALPHA
HYDROXYLASE DOMAIN PROTEIN-2
HISTONE DEMETHYLASE JMJD2B
GENE-EXPRESSION
DNA METHYLATION
BREAST-CANCER
EPIGENETIC REGULATION
VASCULAR DEVELOPMENT
FACTOR (HIF)-1-ALPHA
LYSINE DEMETHYLASE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellsig.2011.08.019

Aref#d: 19770. Division of Gene Regulation and Expression Strategic Award
Blow, J. (Investigator), Hutvagner, G. (Investigator), Lamond, A. (Investigator), Owen-Hughes, T. (Investigator) & Swedlow, J. (Investigator)
1/01/08 → 31/12/12
Project: Research

Cite this

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title = "Chromatin as an oxygen sensor and active player in the hypoxia response",

abstract = "Changes in the availability or demand for oxygen induce dramatic changes at the cellular level. Primarily, activation of a family of oxygen labile transcription factors, Hypoxia Inducible Factor (HIF), initiates a variety of cellular processes required to re-instate oxygen homeostasis. Oxygen is sensed by molecular dioxygenases in cells, such as the prolyl-hydroxylases (PHDs), enzymes which are responsible for the oxygen-dependent regulation of HIF. As HIF is a transcription factor it must bind DNA sequences of its target genes possibly in the context of a complex chromatin structure. How chromatin structure changes in response to hypoxia is currently unknown. However, the identification of a novel class of histone demethylases as true dioxygenases suggests that chromatin can act as an oxygen sensor and plays an active role in the coordination of the cellular response to hypoxia. This review will discuss the current knowledge on how hypoxia engages with different proteins involved in chromatin organisation and dynamics. (C) 2011 Elsevier Inc. All rights reserved.",

keywords = "Hypoxia, Chromatin, HIF, Transcription, Chromatin remodellers, JmjC demethylases, INDUCIBLE FACTOR 1-ALPHA, HYDROXYLASE DOMAIN PROTEIN-2, HISTONE DEMETHYLASE JMJD2B, GENE-EXPRESSION, DNA METHYLATION, BREAST-CANCER, EPIGENETIC REGULATION, VASCULAR DEVELOPMENT, FACTOR (HIF)-1-ALPHA, LYSINE DEMETHYLASE",

author = "Andrew Melvin and Sonia Rocha",

year = "2012",

month = jan,

doi = "10.1016/j.cellsig.2011.08.019",

language = "English",

volume = "24",

pages = "35--43",

journal = "Cellular Signalling",

issn = "0898-6568",

publisher = "Elsevier",

number = "1",

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TY - JOUR

T1 - Chromatin as an oxygen sensor and active player in the hypoxia response

AU - Melvin, Andrew

AU - Rocha, Sonia

PY - 2012/1

Y1 - 2012/1

N2 - Changes in the availability or demand for oxygen induce dramatic changes at the cellular level. Primarily, activation of a family of oxygen labile transcription factors, Hypoxia Inducible Factor (HIF), initiates a variety of cellular processes required to re-instate oxygen homeostasis. Oxygen is sensed by molecular dioxygenases in cells, such as the prolyl-hydroxylases (PHDs), enzymes which are responsible for the oxygen-dependent regulation of HIF. As HIF is a transcription factor it must bind DNA sequences of its target genes possibly in the context of a complex chromatin structure. How chromatin structure changes in response to hypoxia is currently unknown. However, the identification of a novel class of histone demethylases as true dioxygenases suggests that chromatin can act as an oxygen sensor and plays an active role in the coordination of the cellular response to hypoxia. This review will discuss the current knowledge on how hypoxia engages with different proteins involved in chromatin organisation and dynamics. (C) 2011 Elsevier Inc. All rights reserved.

AB - Changes in the availability or demand for oxygen induce dramatic changes at the cellular level. Primarily, activation of a family of oxygen labile transcription factors, Hypoxia Inducible Factor (HIF), initiates a variety of cellular processes required to re-instate oxygen homeostasis. Oxygen is sensed by molecular dioxygenases in cells, such as the prolyl-hydroxylases (PHDs), enzymes which are responsible for the oxygen-dependent regulation of HIF. As HIF is a transcription factor it must bind DNA sequences of its target genes possibly in the context of a complex chromatin structure. How chromatin structure changes in response to hypoxia is currently unknown. However, the identification of a novel class of histone demethylases as true dioxygenases suggests that chromatin can act as an oxygen sensor and plays an active role in the coordination of the cellular response to hypoxia. This review will discuss the current knowledge on how hypoxia engages with different proteins involved in chromatin organisation and dynamics. (C) 2011 Elsevier Inc. All rights reserved.

KW - Hypoxia

KW - Chromatin

KW - HIF

KW - Transcription

KW - Chromatin remodellers

KW - JmjC demethylases

KW - INDUCIBLE FACTOR 1-ALPHA

KW - HYDROXYLASE DOMAIN PROTEIN-2

KW - HISTONE DEMETHYLASE JMJD2B

KW - GENE-EXPRESSION

KW - DNA METHYLATION

KW - BREAST-CANCER

KW - EPIGENETIC REGULATION

KW - VASCULAR DEVELOPMENT

KW - FACTOR (HIF)-1-ALPHA

KW - LYSINE DEMETHYLASE

U2 - 10.1016/j.cellsig.2011.08.019

DO - 10.1016/j.cellsig.2011.08.019

M3 - Review article

C2 - 21924352

SN - 0898-6568

VL - 24

SP - 35

EP - 43

JO - Cellular Signalling

JF - Cellular Signalling

IS - 1

ER -

Chromatin as an oxygen sensor and active player in the hypoxia response

Abstract

Keywords

UN SDGs

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Projects

Aref#d: 19770. Division of Gene Regulation and Expression Strategic Award

Cite this