Chromatin proteins involved in the initiation of DNA replication

Alison Rowles; J. Julian Blow

doi:10.1016/S0959-437X(97)80123-2

Chromatin proteins involved in the initiation of DNA replication

Alison Rowles, J. Julian Blow

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Abstract

Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G₁ to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.

Original language	English
Pages (from-to)	152-157
Number of pages	6
Journal	Current Opinion in Genetics & Development
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S0959-437X(97)80123-2
Publication status	Published - Apr 1997

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title = "Chromatin proteins involved in the initiation of DNA replication",

abstract = "Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.",

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AB - Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.

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DO - 10.1016/S0959-437X(97)80123-2

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JO - Current Opinion in Genetics & Development

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Chromatin proteins involved in the initiation of DNA replication

Abstract

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