Chromatin proteins involved in the initiation of DNA replication

Alison Rowles, J. Julian Blow

    Research output: Contribution to journalArticlepeer-review

    64 Citations (Scopus)


    Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.

    Original languageEnglish
    Pages (from-to)152-157
    Number of pages6
    JournalCurrent Opinion in Genetics & Development
    Issue number2
    Publication statusPublished - Apr 1997


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