Chromatin remodelling comes into focus

Ramasubramian Sundaramoorthy (Lead / Corresponding author), Tom Owen-Hughes

    Research output: Contribution to journalReview articlepeer-review

    10 Citations (Scopus)
    87 Downloads (Pure)

    Abstract

    ATP-dependent chromatin remodelling enzymes are molecular machines that act to reconfigure the structure of nucleosomes. Until recently, little was known about the structure of these enzymes. Recent progress has revealed that their interaction with chromatin is dominated by ATPase domains that contact DNA at favoured locations on the nucleosome surface. Contacts with histones are limited but play important roles in modulating activity. The ATPase domains do not act in isolation but are flanked by diverse accessory domains and subunits. New structures indicate how these subunits are arranged in multi-subunit complexes providing a framework from which to understand how a common motor is applied to distinct functions.

    Original languageEnglish
    Article number1011
    Number of pages14
    JournalF1000Research
    Volume9
    DOIs
    Publication statusPublished - 20 Aug 2020

    Keywords

    • BAF.
    • CHD1
    • INO80
    • SMARCA
    • SWI/SNF complex
    • SWR1
    • chromatin remodelling
    • nucleosome structure
    • Chromatin remodelling
    • BAF
    • Nucleosome structure

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology
    • General Immunology and Microbiology
    • Pharmacology, Toxicology and Pharmaceutics(all)

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