Chromatin Replication and Histone Dynamics

Constance Alabert, Zuzana Jasencakova, Anja Groth (Lead / Corresponding author)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

    35 Citations (Scopus)

    Abstract

    Inheritance of the DNA sequence and its proper organization into chromatin is fundamental for genome stability and function. Therefore, how specific chromatin structures are restored on newly synthesized DNA and transmitted through cell division remains a central question to understand cell fate choices and self-renewal. Propagation of genetic information and chromatin-based information in cycling cells entails genome-wide disruption and restoration of chromatin, coupled with faithful replication of DNA. In this chapter, we describe how cells duplicate the genome while maintaining its proper organization into chromatin. We reveal how specialized replication-coupled mechanisms rapidly assemble newly synthesized DNA into nucleosomes, while the complete restoration of chromatin organization including histone marks is a continuous process taking place throughout the cell cycle. Because failure to reassemble nucleosomes at replication forks blocks DNA replication progression in higher eukaryotes and leads to genomic instability, we further underline the importance of the mechanistic link between DNA replication and chromatin duplication.

    Original languageEnglish
    Title of host publicationDNA Replication
    Subtitle of host publicationFrom Old Principles to New Discoveries
    EditorsHisao Masai, Marco Foiani
    Place of PublicationSingapore
    PublisherSpringer Nature
    Pages311-333
    Number of pages23
    ISBN (Electronic)9789811069550
    ISBN (Print)9789811069543
    DOIs
    Publication statusPublished - 2017

    Publication series

    NameAdvances in Experimental Medicine and Biology
    PublisherSpringer Nature
    Volume1042
    ISSN (Print)0065-2598
    ISSN (Electronic)2214-8019

    Keywords

    • Journal article
    • DNA replication
    • Nucleosome assembly
    • Histone chaperone
    • Histone recycling
    • Chromatin
    • Epigenetics

    Fingerprint

    Dive into the research topics of 'Chromatin Replication and Histone Dynamics'. Together they form a unique fingerprint.

    Cite this