Chromatin Replication and Histone Dynamics

Constance Alabert, Zuzana Jasencakova, Anja Groth (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

30 Citations (Scopus)


Inheritance of the DNA sequence and its proper organization into chromatin is fundamental for genome stability and function. Therefore, how specific chromatin structures are restored on newly synthesized DNA and transmitted through cell division remains a central question to understand cell fate choices and self-renewal. Propagation of genetic information and chromatin-based information in cycling cells entails genome-wide disruption and restoration of chromatin, coupled with faithful replication of DNA. In this chapter, we describe how cells duplicate the genome while maintaining its proper organization into chromatin. We reveal how specialized replication-coupled mechanisms rapidly assemble newly synthesized DNA into nucleosomes, while the complete restoration of chromatin organization including histone marks is a continuous process taking place throughout the cell cycle. Because failure to reassemble nucleosomes at replication forks blocks DNA replication progression in higher eukaryotes and leads to genomic instability, we further underline the importance of the mechanistic link between DNA replication and chromatin duplication.

Original languageEnglish
Title of host publicationDNA Replication
Subtitle of host publicationFrom Old Principles to New Discoveries
EditorsHisao Masai, Marco Foiani
Place of PublicationSingapore
PublisherSpringer Nature
Number of pages23
ISBN (Electronic)9789811069550
ISBN (Print)9789811069543
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer Nature
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Journal article
  • DNA replication
  • Nucleosome assembly
  • Histone chaperone
  • Histone recycling
  • Chromatin
  • Epigenetics


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