Chromogranin A levels and mortality in patients with severe sepsis

Chih-Hsin Hsu; Luis F. Reyes; Carlos J. Orihuela; Ricardo Buitrago; Antonio Anzueto; Nilam J. Soni; Stephanie Levine; Jay Peters; Cecilia A. Hinojosa; Stefano Aliberti; Oriol Sibila; Alejandro Rodriguez; James D. Chalmers; Ignacio Martin-Loeches; Jose Bordon; Jose Blanquer; Francisco Sanz; Pedro J. Marcos; Jordi Rello; Jordi Solé-Violán; Marcos I. Restrepo

doi:10.3109/1354750X.2015.1046932

Chromogranin A levels and mortality in patients with severe sepsis

Chih-Hsin Hsu, Luis F. Reyes, Carlos J. Orihuela, Ricardo Buitrago, Antonio Anzueto, Nilam J. Soni, Stephanie Levine, Jay Peters, Cecilia A. Hinojosa, Stefano Aliberti, Oriol Sibila, Alejandro Rodriguez, James D. Chalmers, Ignacio Martin-Loeches, Jose Bordon, Jose Blanquer, Francisco Sanz, Pedro J. Marcos, Jordi Rello, Jordi Solé-ViolánMarcos I. Restrepo (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

Original language	English
Pages (from-to)	171-176
Number of pages	6
Journal	Biomarkers
Volume	20
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2015.1046932
Publication status	Published - 2015

Keywords

Biological marker
Cardiovascular diseases
Chromogranin A
Mortality
Sepsis

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/1354750X.2015.1046932

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Hsu, C.-H., Reyes, L. F., Orihuela, C. J., Buitrago, R., Anzueto, A., Soni, N. J., Levine, S., Peters, J., Hinojosa, C. A., Aliberti, S., Sibila, O., Rodriguez, A., Chalmers, J. D., Martin-Loeches, I., Bordon, J., Blanquer, J., Sanz, F., Marcos, P. J., Rello, J., ... Restrepo, M. I. (2015). Chromogranin A levels and mortality in patients with severe sepsis. Biomarkers, 20(3), 171-176. https://doi.org/10.3109/1354750X.2015.1046932

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title = "Chromogranin A levels and mortality in patients with severe sepsis",

abstract = "Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.",

keywords = "Biological marker, Cardiovascular diseases, Chromogranin A, Mortality, Sepsis",

author = "Chih-Hsin Hsu and Reyes, {Luis F.} and Orihuela, {Carlos J.} and Ricardo Buitrago and Antonio Anzueto and Soni, {Nilam J.} and Stephanie Levine and Jay Peters and Hinojosa, {Cecilia A.} and Stefano Aliberti and Oriol Sibila and Alejandro Rodriguez and Chalmers, {James D.} and Ignacio Martin-Loeches and Jose Bordon and Jose Blanquer and Francisco Sanz and Marcos, {Pedro J.} and Jordi Rello and Jordi Sol{\'e}-Viol{\'a}n and Restrepo, {Marcos I.}",

year = "2015",

doi = "10.3109/1354750X.2015.1046932",

language = "English",

volume = "20",

pages = "171--176",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor & Francis",

number = "3",

}

Hsu, C-H, Reyes, LF, Orihuela, CJ, Buitrago, R, Anzueto, A, Soni, NJ, Levine, S, Peters, J, Hinojosa, CA, Aliberti, S, Sibila, O, Rodriguez, A, Chalmers, JD, Martin-Loeches, I, Bordon, J, Blanquer, J, Sanz, F, Marcos, PJ, Rello, J, Solé-Violán, J & Restrepo, MI 2015, 'Chromogranin A levels and mortality in patients with severe sepsis', Biomarkers, vol. 20, no. 3, pp. 171-176. https://doi.org/10.3109/1354750X.2015.1046932

TY - JOUR

T1 - Chromogranin A levels and mortality in patients with severe sepsis

AU - Hsu, Chih-Hsin

AU - Reyes, Luis F.

AU - Orihuela, Carlos J.

AU - Buitrago, Ricardo

AU - Anzueto, Antonio

AU - Soni, Nilam J.

AU - Levine, Stephanie

AU - Peters, Jay

AU - Hinojosa, Cecilia A.

AU - Aliberti, Stefano

AU - Sibila, Oriol

AU - Rodriguez, Alejandro

AU - Chalmers, James D.

AU - Martin-Loeches, Ignacio

AU - Bordon, Jose

AU - Blanquer, Jose

AU - Sanz, Francisco

AU - Marcos, Pedro J.

AU - Rello, Jordi

AU - Solé-Violán, Jordi

AU - Restrepo, Marcos I.

PY - 2015

Y1 - 2015

N2 - Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

AB - Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

KW - Biological marker

KW - Cardiovascular diseases

KW - Chromogranin A

KW - Mortality

KW - Sepsis

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U2 - 10.3109/1354750X.2015.1046932

DO - 10.3109/1354750X.2015.1046932

M3 - Article

C2 - 26154393

AN - SCOPUS:84940027182

SN - 1354-750X

VL - 20

SP - 171

EP - 176

JO - Biomarkers

JF - Biomarkers

IS - 3

ER -

Chromogranin A levels and mortality in patients with severe sepsis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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