Chromosomal aberrations in renal cell carcinoma: An overview with implications for clinical practice

Muhammad Quddus, Norman Pratt, Ghulam Nabi (Lead / Corresponding author)

Research output: Contribution to journalReview article

34 Downloads (Pure)

Abstract

Chromosomal instability and aberrations are known in many cancers including renal cell carcinoma. Detailed understanding of these changes has led to an improved drug discovery and continued developments in other therapeutic options. Chromosomal aberrations have a potential to be used to monitor disease including prognostication. There has been a growing experience in cytogenetic techniques and gap between clinic and laboratory has narrowed significantly in the recent past. Nevertheless, more work on validation of these techniques, establishing threshold and interobserver agreement needs to be carried out for these diagnostic/prognostic tests before utilizing them in clinics as a part of 'personalized medicine' care. The review presented here is a summary of common genetic disorders in renal cancer and some of acquired genetic changes which can be used as biomarkers. The review also describes basics of commonly used genetic techniques for wider clinical community involved in the management of renal cancer.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalUrology Annals
Volume11
Issue number1
Early online date21 Jan 2019
DOIs
Publication statusPublished - 23 Feb 2019

Fingerprint

Kidney Neoplasms
Renal Cell Carcinoma
Chromosome Aberrations
Genetic Techniques
Chromosomal Instability
Precision Medicine
Inborn Genetic Diseases
Cytogenetic Analysis
Drug Discovery
Routine Diagnostic Tests
Biomarkers
Neoplasms
Therapeutics

Keywords

  • Chromosome
  • clear-cell carcinoma
  • genetics
  • head and neck cancer
  • head and neck squamous cell carcinoma
  • intensity modulated radiotherapy
  • radiotherapy kidney
  • renal cell cancer
  • three-dimensional conformal radiotherapy
  • toxicity
  • xerostomia

Cite this

@article{9af2e50a4221488a9d085d86a9d61b35,
title = "Chromosomal aberrations in renal cell carcinoma: An overview with implications for clinical practice",
abstract = "Chromosomal instability and aberrations are known in many cancers including renal cell carcinoma. Detailed understanding of these changes has led to an improved drug discovery and continued developments in other therapeutic options. Chromosomal aberrations have a potential to be used to monitor disease including prognostication. There has been a growing experience in cytogenetic techniques and gap between clinic and laboratory has narrowed significantly in the recent past. Nevertheless, more work on validation of these techniques, establishing threshold and interobserver agreement needs to be carried out for these diagnostic/prognostic tests before utilizing them in clinics as a part of 'personalized medicine' care. The review presented here is a summary of common genetic disorders in renal cancer and some of acquired genetic changes which can be used as biomarkers. The review also describes basics of commonly used genetic techniques for wider clinical community involved in the management of renal cancer.",
keywords = "Chromosome, clear-cell carcinoma, genetics, head and neck cancer, head and neck squamous cell carcinoma, intensity modulated radiotherapy, radiotherapy kidney, renal cell cancer, three-dimensional conformal radiotherapy, toxicity, xerostomia",
author = "Muhammad Quddus and Norman Pratt and Ghulam Nabi",
year = "2019",
month = "2",
day = "23",
doi = "10.4103/UA.UA_32_18",
language = "English",
volume = "11",
pages = "6--14",
journal = "Urology Annals",
issn = "0974-7796",
publisher = "Medknow Publications",
number = "1",

}

Chromosomal aberrations in renal cell carcinoma : An overview with implications for clinical practice. / Quddus, Muhammad; Pratt, Norman; Nabi, Ghulam (Lead / Corresponding author).

In: Urology Annals, Vol. 11, No. 1, 23.02.2019, p. 6-14.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Chromosomal aberrations in renal cell carcinoma

T2 - An overview with implications for clinical practice

AU - Quddus, Muhammad

AU - Pratt, Norman

AU - Nabi, Ghulam

PY - 2019/2/23

Y1 - 2019/2/23

N2 - Chromosomal instability and aberrations are known in many cancers including renal cell carcinoma. Detailed understanding of these changes has led to an improved drug discovery and continued developments in other therapeutic options. Chromosomal aberrations have a potential to be used to monitor disease including prognostication. There has been a growing experience in cytogenetic techniques and gap between clinic and laboratory has narrowed significantly in the recent past. Nevertheless, more work on validation of these techniques, establishing threshold and interobserver agreement needs to be carried out for these diagnostic/prognostic tests before utilizing them in clinics as a part of 'personalized medicine' care. The review presented here is a summary of common genetic disorders in renal cancer and some of acquired genetic changes which can be used as biomarkers. The review also describes basics of commonly used genetic techniques for wider clinical community involved in the management of renal cancer.

AB - Chromosomal instability and aberrations are known in many cancers including renal cell carcinoma. Detailed understanding of these changes has led to an improved drug discovery and continued developments in other therapeutic options. Chromosomal aberrations have a potential to be used to monitor disease including prognostication. There has been a growing experience in cytogenetic techniques and gap between clinic and laboratory has narrowed significantly in the recent past. Nevertheless, more work on validation of these techniques, establishing threshold and interobserver agreement needs to be carried out for these diagnostic/prognostic tests before utilizing them in clinics as a part of 'personalized medicine' care. The review presented here is a summary of common genetic disorders in renal cancer and some of acquired genetic changes which can be used as biomarkers. The review also describes basics of commonly used genetic techniques for wider clinical community involved in the management of renal cancer.

KW - Chromosome

KW - clear-cell carcinoma

KW - genetics

KW - head and neck cancer

KW - head and neck squamous cell carcinoma

KW - intensity modulated radiotherapy

KW - radiotherapy kidney

KW - renal cell cancer

KW - three-dimensional conformal radiotherapy

KW - toxicity

KW - xerostomia

UR - http://www.scopus.com/inward/record.url?scp=85060434753&partnerID=8YFLogxK

U2 - 10.4103/UA.UA_32_18

DO - 10.4103/UA.UA_32_18

M3 - Review article

VL - 11

SP - 6

EP - 14

JO - Urology Annals

JF - Urology Annals

SN - 0974-7796

IS - 1

ER -