Chromosome bi-orientation on the mitotic spindle

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    For proper chromosome segregation, sister kinetochores must attach to microtubules extending from opposite spindle poles prior to anaphase onset. This state is called sister kinetochore bi-orientation or chromosome bi-orientation. The mechanism ensuring chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent evidence suggests that mal-oriented kinetochore-to-pole connections are corrected in a tension-dependent mechanism. The cohesin complex and the Ipl1/Aurora B protein kinase seem to be key regulators for this correction. In this article, I discuss how cells ensure sister kinetochore bi-orientation for all chromosomes, mainly focusing on our recent findings in budding yeast.
    Original languageEnglish
    Pages (from-to)581-9
    Number of pages9
    JournalPhilosophical Transactions of the Royal Society B - Biological Sciences
    Issue number1455
    Publication statusPublished - 2005

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