Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma

Neil C. Thomson (Lead / Corresponding author), Rekha Chaudhuri, C. Martina Messow, Mark Spears, William Macnee, Martin Connell, John T. Murchison, Michael Sproule, Charles McSharry

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)
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Background Chronic cough and sputum production (chronic mucus hypersecretion) is a poorly described clinical feature of asthma. Our objective was to identify clinical, immunological and computed tomography (CT) measures of airway wall dimensions associated with these symptoms in smokers and never smokers with asthma. Methods Cross-sectional data was analysed from 120 smokers and never smokers with asthma. Participants with and without a history of chronic mucus hypersecretion were compared for clinical outcomes, sputum differential cell counts and CT measures of airway dimensions (wall thickness, luminal area and percent wall area). Results Chronic mucus hypersecretion occurred in a higher proportion of smokers with asthma (56%) than never smokers with asthma (20%), (p < 0.001) and the proportion of patients with these symptoms increased with asthma severity (p = 0.003). Smokers with asthma and chronic mucus hypersecretion had worse current clinical control than smokers without those symptoms [ACQ score 2.3 versus 1.6, p = 0.002]. A greater proportion of never smokers with chronic mucus hypersecretion required short courses of oral corticosteroids in the last year (58% versus 19%, p = 0.011). Sputum neutrophil and eosinophil counts were similar in asthma patients with or without chronic mucus hypersecretion. Of those with severe asthma and chronic mucus hypersecretion, a CT measure of airway lumen area was reduced in smokers compared to never smokers (11.4 mm2 versus 18.4 mm2; p = 0.017). Conclusions Chronic mucus hypersecretion occurs frequently in adults with stable asthma, particularly in smokers with severe disease and is associated with worse current clinical control in smokers and more exacerbations in never smokers.

Original languageEnglish
Pages (from-to)1501-1508
Number of pages8
JournalRespiratory Medicine
Issue number10
Early online date7 Aug 2013
Publication statusPublished - 1 Oct 2013


  • Asthma
  • Asthma control
  • Cough
  • Exacerbations
  • Smokers
  • Sputum

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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