Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

Yejin Mok; Aditya Surapaneni; Yingying Sang; Josef Coresh; Morgan E. Grams; Kunihiro Matsushita; Shoshana H. Ballew; Natalia Alencar de Pinho; Johan Ärnlöv; Sandhi M. Barreto; Samira Bell; Hermann Brenner; Juan Jesus Carrero; Rajkumar Chinnadurai; Elizabeth Ciemins; Ron T. Gansevoort; Simerjot K. Jassal; Keum Ji Jung; H. Lester Kirchner; Tsuneo Konta; Csaba P. Kovesdy; Li Luo; Krutika Pandit; Mahboob Rahman; Cassianne Robinson-Cohen; Charumathi Sabanayagam; Ulla T. Schultheiss; Michael Shlipak; Natalie Staplin; Marcello Tonelli; Angela Yee Moon Wang; Chi Pang Wen; Mark Woodward; Jennifer S. Lees

doi:10.1038/s41416-025-03140-z

Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

Yejin Mok
, Aditya Surapaneni
, Yingying Sang
, Josef Coresh
, Morgan E. Grams
, Kunihiro Matsushita
, Shoshana H. Ballew (Lead / Corresponding author)
, Natalia Alencar de Pinho
, Johan Ärnlöv
, Sandhi M. Barreto
, Samira Bell
, Hermann Brenner
, Juan Jesus Carrero
, Rajkumar Chinnadurai
, Elizabeth Ciemins
, Ron T. Gansevoort
, Simerjot K. Jassal
, Keum Ji Jung
, H. Lester Kirchner
, Tsuneo Konta

Csaba P. Kovesdy, Li Luo, Krutika Pandit, Mahboob Rahman, Cassianne Robinson-Cohen, Charumathi Sabanayagam, Ulla T. Schultheiss, Michael Shlipak, Natalie Staplin, Marcello Tonelli, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Jennifer S. Lees,

Population Health and Genomics

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

7 Downloads (Pure)

Abstract

BACKGROUND: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. METHODS: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure. RESULTS: Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. DISCUSSION: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

Original language	English
Pages (from-to)	1535-1543
Number of pages	9
Journal	British Journal of Cancer
Volume	133
Issue number	10
Early online date	6 Sept 2025
DOIs	https://doi.org/10.1038/s41416-025-03140-z
Publication status	Published - 30 Nov 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/s41416-025-03140-zLicence: CC BY

Final published version
Copyright © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 968 KBLicence: CC BY

Cite this

Mok, Y., Surapaneni, A., Sang, Y., Coresh, J., Grams, M. E., Matsushita, K., Ballew, S. H., Alencar de Pinho, N., Ärnlöv, J., Barreto, S. M., Bell, S., Brenner, H., Carrero, J. J., Chinnadurai, R., Ciemins, E., Gansevoort, R. T., Jassal, S. K., Jung, K. J., Kirchner, H. L. (2025). Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis. British Journal of Cancer, 133(10), 1535-1543. https://doi.org/10.1038/s41416-025-03140-z

@article{da2e3874cf354952a65eb44ab0fe87a1,

title = "Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis",

abstract = "BACKGROUND: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. METHODS: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure. RESULTS: Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95\% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. DISCUSSION: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.",

author = "Yejin Mok and Aditya Surapaneni and Yingying Sang and Josef Coresh and Grams, \{Morgan E.\} and Kunihiro Matsushita and Ballew, \{Shoshana H.\} and \{Alencar de Pinho\}, Natalia and Johan {\"A}rnl{\"o}v and Barreto, \{Sandhi M.\} and Samira Bell and Hermann Brenner and Carrero, \{Juan Jesus\} and Rajkumar Chinnadurai and Elizabeth Ciemins and Gansevoort, \{Ron T.\} and Jassal, \{Simerjot K.\} and Jung, \{Keum Ji\} and Kirchner, \{H. Lester\} and Tsuneo Konta and Kovesdy, \{Csaba P.\} and Li Luo and Krutika Pandit and Mahboob Rahman and Cassianne Robinson-Cohen and Charumathi Sabanayagam and Schultheiss, \{Ulla T.\} and Michael Shlipak and Natalie Staplin and Marcello Tonelli and Wang, \{Angela Yee Moon\} and Wen, \{Chi Pang\} and Mark Woodward and Lees, \{Jennifer S.\}",

note = "Copyright {\textcopyright} 2025. The Author(s).",

year = "2025",

month = nov,

day = "30",

doi = "10.1038/s41416-025-03140-z",

language = "English",

volume = "133",

pages = "1535--1543",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "10",

}

Mok, Y, Surapaneni, A, Sang, Y, Coresh, J, Grams, ME, Matsushita, K, Ballew, SH, Alencar de Pinho, N, Ärnlöv, J, Barreto, SM, Bell, S, Brenner, H, Carrero, JJ, Chinnadurai, R, Ciemins, E, Gansevoort, RT, Jassal, SK, Jung, KJ, Kirchner, HL, Konta, T, Kovesdy, CP, Luo, L, Pandit, K, Rahman, M, Robinson-Cohen, C, Sabanayagam, C, Schultheiss, UT, Shlipak, M, Staplin, N, Tonelli, M, Wang, AYM, Wen, CP, Woodward, M, Lees, JS 2025, 'Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis', British Journal of Cancer, vol. 133, no. 10, pp. 1535-1543. https://doi.org/10.1038/s41416-025-03140-z

TY - JOUR

T1 - Chronic kidney disease and incident cancer risk

T2 - an individual participant data meta-analysis

AU - Mok, Yejin

AU - Surapaneni, Aditya

AU - Sang, Yingying

AU - Coresh, Josef

AU - Grams, Morgan E.

AU - Matsushita, Kunihiro

AU - Ballew, Shoshana H.

AU - Alencar de Pinho, Natalia

AU - Ärnlöv, Johan

AU - Barreto, Sandhi M.

AU - Bell, Samira

AU - Brenner, Hermann

AU - Carrero, Juan Jesus

AU - Chinnadurai, Rajkumar

AU - Ciemins, Elizabeth

AU - Gansevoort, Ron T.

AU - Jassal, Simerjot K.

AU - Jung, Keum Ji

AU - Kirchner, H. Lester

AU - Konta, Tsuneo

AU - Kovesdy, Csaba P.

AU - Luo, Li

AU - Pandit, Krutika

AU - Rahman, Mahboob

AU - Robinson-Cohen, Cassianne

AU - Sabanayagam, Charumathi

AU - Schultheiss, Ulla T.

AU - Shlipak, Michael

AU - Staplin, Natalie

AU - Tonelli, Marcello

AU - Wang, Angela Yee Moon

AU - Wen, Chi Pang

AU - Woodward, Mark

AU - Lees, Jennifer S.

PY - 2025/11/30

Y1 - 2025/11/30

N2 - BACKGROUND: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. METHODS: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure. RESULTS: Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. DISCUSSION: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

AB - BACKGROUND: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. METHODS: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure. RESULTS: Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. DISCUSSION: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

UR - https://www.scopus.com/pages/publications/105021352805

U2 - 10.1038/s41416-025-03140-z

DO - 10.1038/s41416-025-03140-z

M3 - Article

C2 - 40914744

AN - SCOPUS:105021352805

SN - 0007-0920

VL - 133

SP - 1535

EP - 1543

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

Abstract

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this