Cilia and Flagella

Patricia Goggin; Amelia Shoemark

doi:10.1201/9781003498551-16

Cilia and Flagella

Patricia Goggin
, Amelia Shoemark

Respiratory Medicine and Gastroenterology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cilia and flagella are microscopic hair-like organelles that protrude from the cell surface. This chapter describes the ultrastructure of motile cilia and flagella and solitary primary cilia. The description includes basal bodies, ciliary tips, and the core microtubular structure of the axoneme in health and disease. Differences in ciliary structure are discussed in relation to the diverse functions of cilia and flagella. Examples are given of atypical findings of ciliary ultrastructure due to inherited ciliopathies and more commonly acquired ciliary defects. The chapter focuses on ultrastructural changes in the inherited condition primary ciliary dyskinesia where transmission electron microscopy analysis is used to confirm a diagnosis.

Original language	English
Title of host publication	Ghadially’s Ultrastructural Pathology of the Cell and Matrix,
Editors	Bart Wagner, John Stirling
Place of Publication	Boca Raton
Publisher	CRC Press
Chapter	16
Pages	690-706
Number of pages	17
Edition	5
ISBN (Electronic)	9781040312605, 9781003498551
ISBN (Print)	9781032811895, 9781032811901
DOIs	https://doi.org/10.1201/9781003498551-16
Publication status	Published - 30 Jul 2025

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology
General Engineering

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10.1201/9781003498551-16

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AB - Cilia and flagella are microscopic hair-like organelles that protrude from the cell surface. This chapter describes the ultrastructure of motile cilia and flagella and solitary primary cilia. The description includes basal bodies, ciliary tips, and the core microtubular structure of the axoneme in health and disease. Differences in ciliary structure are discussed in relation to the diverse functions of cilia and flagella. Examples are given of atypical findings of ciliary ultrastructure due to inherited ciliopathies and more commonly acquired ciliary defects. The chapter focuses on ultrastructural changes in the inherited condition primary ciliary dyskinesia where transmission electron microscopy analysis is used to confirm a diagnosis.

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Cilia and Flagella

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