Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

Mahmud K. K. Shivji, Sara J. Grey, Ulrich P. Strausfeld, Richard D. Wood, J. Julian Blow

    Research output: Contribution to journalArticlepeer-review

    133 Citations (Scopus)

    Abstract

    DNA that is damaged by ultraviolet (UV) light is repaired predominantly by nucleotide excision-repair, a process requiring the DNA polymerase auxiliary factor PCNA. UV-irradiation also induces the production of Cip1 protein via activation of p53. Cip1 is an inhibitor of the cyclin-dependent kinases, which are required for the cell cycle to proceed through the G1/S-phase transition and initiate DNA replication. Inhibition by Cip1 probably causes the block to initiation of DNA replication that is seen in irradiated cells. Cip1 also directly inhibits the function of PCNA during DNA synthesis. As nucleotide excision-repair requires PCNA, the physiological relevance of PCNA inhibition by Cip1 is currently unclear.
    Original languageEnglish
    Pages (from-to)1062-1068
    Number of pages7
    JournalCurrent Biology
    Volume4
    Issue number12
    DOIs
    Publication statusPublished - 1 Dec 1994

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