Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

Mahmud K. K. Shivji; Sara J. Grey; Ulrich P. Strausfeld; Richard D. Wood; J. Julian Blow

doi:10.1016/S0960-9822(00)00244-X

Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

Mahmud K. K. Shivji, Sara J. Grey, Ulrich P. Strausfeld, Richard D. Wood, J. Julian Blow

Research output: Contribution to journal › Article › peer-review

144 Citations (Scopus)

Abstract

DNA that is damaged by ultraviolet (UV) light is repaired predominantly by nucleotide excision-repair, a process requiring the DNA polymerase auxiliary factor PCNA. UV-irradiation also induces the production of Cip1 protein via activation of p53. Cip1 is an inhibitor of the cyclin-dependent kinases, which are required for the cell cycle to proceed through the G1/S-phase transition and initiate DNA replication. Inhibition by Cip1 probably causes the block to initiation of DNA replication that is seen in irradiated cells. Cip1 also directly inhibits the function of PCNA during DNA synthesis. As nucleotide excision-repair requires PCNA, the physiological relevance of PCNA inhibition by Cip1 is currently unclear.

Original language	English
Pages (from-to)	1062-1068
Number of pages	7
Journal	Current Biology
Volume	4
Issue number	12
DOIs	https://doi.org/10.1016/S0960-9822(00)00244-X
Publication status	Published - 1 Dec 1994

Access to Document

10.1016/S0960-9822(00)00244-X

Cite this

@article{ab65aa459ef743b69101ad5ec0e15e9c,

title = "Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair",

abstract = "DNA that is damaged by ultraviolet (UV) light is repaired predominantly by nucleotide excision-repair, a process requiring the DNA polymerase auxiliary factor PCNA. UV-irradiation also induces the production of Cip1 protein via activation of p53. Cip1 is an inhibitor of the cyclin-dependent kinases, which are required for the cell cycle to proceed through the G1/S-phase transition and initiate DNA replication. Inhibition by Cip1 probably causes the block to initiation of DNA replication that is seen in irradiated cells. Cip1 also directly inhibits the function of PCNA during DNA synthesis. As nucleotide excision-repair requires PCNA, the physiological relevance of PCNA inhibition by Cip1 is currently unclear.",

author = "Shivji, {Mahmud K. K.} and Grey, {Sara J.} and Strausfeld, {Ulrich P.} and Wood, {Richard D.} and Blow, {J. Julian}",

year = "1994",

month = dec,

day = "1",

doi = "10.1016/S0960-9822(00)00244-X",

language = "English",

volume = "4",

pages = "1062--1068",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "12",

}

TY - JOUR

T1 - Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

AU - Shivji, Mahmud K. K.

AU - Grey, Sara J.

AU - Strausfeld, Ulrich P.

AU - Wood, Richard D.

AU - Blow, J. Julian

PY - 1994/12/1

Y1 - 1994/12/1

N2 - DNA that is damaged by ultraviolet (UV) light is repaired predominantly by nucleotide excision-repair, a process requiring the DNA polymerase auxiliary factor PCNA. UV-irradiation also induces the production of Cip1 protein via activation of p53. Cip1 is an inhibitor of the cyclin-dependent kinases, which are required for the cell cycle to proceed through the G1/S-phase transition and initiate DNA replication. Inhibition by Cip1 probably causes the block to initiation of DNA replication that is seen in irradiated cells. Cip1 also directly inhibits the function of PCNA during DNA synthesis. As nucleotide excision-repair requires PCNA, the physiological relevance of PCNA inhibition by Cip1 is currently unclear.

AB - DNA that is damaged by ultraviolet (UV) light is repaired predominantly by nucleotide excision-repair, a process requiring the DNA polymerase auxiliary factor PCNA. UV-irradiation also induces the production of Cip1 protein via activation of p53. Cip1 is an inhibitor of the cyclin-dependent kinases, which are required for the cell cycle to proceed through the G1/S-phase transition and initiate DNA replication. Inhibition by Cip1 probably causes the block to initiation of DNA replication that is seen in irradiated cells. Cip1 also directly inhibits the function of PCNA during DNA synthesis. As nucleotide excision-repair requires PCNA, the physiological relevance of PCNA inhibition by Cip1 is currently unclear.

U2 - 10.1016/S0960-9822(00)00244-X

DO - 10.1016/S0960-9822(00)00244-X

M3 - Article

C2 - 7704570

SN - 0960-9822

VL - 4

SP - 1062

EP - 1068

JO - Current Biology

JF - Current Biology

IS - 12

ER -

Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

Abstract

Access to Document

Fingerprint

Cite this