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Abstract
Aim: To investigate the count of circulating tissue factor-positive (TF +) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM).
Methods: This case-control study included patients with T1DM and age and sex-matched healthy volunteers. The counts of phosphatidylserine-positive (PS +) MPs and TF +PS +MPs and the subgroups derived from different cell types were measured in the peripheral blood sample of the two groups using multicolor flow cytometric assay. We compared the counts of each MP between groups as well as the ratio of the TF +PS +MPs and PS +MPs (TF +PS +MPs/PS +MPs).
Results: We recruited 36 patients with T1DM and 36 matched healthy controls. Compared with healthy volunteers, PS +MPs, TF +PS +MPs and TF +PS +MPs/PS +MPs were elevated in patients with T1DM (PS +MPs: 1078.5 ± 158.08 vs 686.84 ± 122.04/μL, P <0.001; TF + PS +MPs: 202.10 ± 47.47 vs 108.33 ± 29.42/μL, P <0.001; and TF +PS +MPs/PS +MPs: 0.16 ± 0.04 vs 0.19 ± 0.05, P = 0.004), mostly derived from platelet, lymphocytes and endothelial cells. In the subgroup analysis, the counts of total and platelet TF +PS +MPs were increased in patients with diabetic retinopathy (DR) and with higher HbA1c, respectively.
Conclusion: Circulating TF +PS +MPs and those derived from platelet, lymphocytes and endothelial cells were elevated in patients with T1DM.
Original language | English |
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Pages (from-to) | 2819-2828 |
Number of pages | 10 |
Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
Volume | 12 |
DOIs | |
Publication status | Published - 3 Jan 2020 |
Keywords
- Diabetic retinopathy
- Microparticles
- Tissue factor
- Type 1 diabetes mellitus
- type 1 diabetes mellitus
- tissue factor
- microparticles
- diabetic retinopathy
ASJC Scopus subject areas
- Internal Medicine
- Pharmacology
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- 3 Finished
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Meformin-Associated B12 Deficiency and Cognitive Function in Type 2 Diabetes
Doney, A. (Investigator), Kang, L. (Investigator), McCrimmon, R. (Investigator) & Pearson, E. (Investigator)
1/09/19 → 29/02/20
Project: Research
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Targeting Early Extracellular Matrix Abnormalities to Treat Cardiac Insulin Resistance and Associated Dysfunction (Joint with University of Glasgow)
Kang, L. (Investigator) & Lang, C. (Investigator)
6/03/19 → 18/12/22
Project: Research
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Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)
Pearson, E. (Investigator)
16/02/15 → 15/08/21
Project: Research
Profiles
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Kang, Li
- Diabetes Endocrinology and Reproductive Biology - Reader (Teaching and Research)
Person: Academic