Abstract
Peroxisome proliferator activated reporter γ(PPARγ) is the subject of intense investigation as a target for drugs against diabetes, atherosclerosis and cancer. For this reason there is considerable interest in the spectrum of compounds that bind this receptor. In this paper we have identified cis-parinaric acid (CPA) as a novel hPPARγ ligand. The binding of this fatty acid to the receptor increases its fluorescence and causes a shift in the UV spectrum. This spectral shift is reversible by competition with other known ligands for PPARγ. This report represents the first direct demonstration of a fatty acid binding to PPARγ.
| Original language | English |
|---|---|
| Pages (from-to) | 476-480 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 431 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 24 Jul 1998 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anti-diabetes drug
- Fatty acid
- Fluorescence
- Nuclear receptor
- Peroxisome proliferator
- Spectrophotometry
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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