Classic biphasic pulmonary blastoma (CBPB): a rare primary pulmonary malignancy

Shashank Pooniya (Lead / Corresponding author), Angela McKinnie, Thomas Taylor, Malcolm Will, William Wallace

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Classic biphasic pulmonary blastoma (CBPB) is a very rare primary pulmonary malignancy with distinctive clinical and pathological features. Usually CBPB presents with either non specific symptoms or is diagnosed incidentally. Histologically CBPB is composed of a mixture of malignant epithelial and stromal cells resembling fetal lung tissue. Surgical resection is the mainstay of treatment with further chemotherapy or radiotherapy on a case-by-case basis. However, due to its rarity, no definite treatment guidelines are available. CBPB overall has a very poor prognosis with a 5-year survival rate of only 15%. Our patient presented with cough and haemoptysis. Her chest radiograph demonstrated a large right-sided lung mass. Further investigations included CT, CT-guided biopsy and PET CT which were discussed at multidisciplinary team meetings. The patient then underwent complete surgical excision. We report this rare malignancy with radiological and pathological features, comparing them with previously reported cases.

Original languageEnglish
Article numbere244151
Number of pages4
JournalBMJ Case Reports
Issue number8
Publication statusPublished - 10 Aug 2021


  • Female
  • Humans
  • Lung
  • Lung Neoplasms/diagnostic imaging
  • Prognosis
  • Pulmonary Blastoma/diagnostic imaging
  • Tomography, X-Ray Computed
  • cardiothoracic surgery
  • pathology
  • radiology
  • lung cancer (oncology)

ASJC Scopus subject areas

  • General Medicine


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