TY - JOUR
T1 - Classification of Protein- Serine/Threonine Phosphatases
T2 - Identification and Quantitation in Cell Extracts
AU - Cohen, Philip
PY - 1991
Y1 - 1991
N2 - This chapter discusses the classification of protein-serine/threonine phosphatases. These enzymes are divided into two groups—type 1 and type 2, depending on whether they dephosphorylate the β subunit of phosphorylase kinase specifically and are inhibited by nanomolar concentrations, or whether they dephosphorylate the α subunit of phosphorylase kinase preferentially and are insensitive to inhibitors 1 and 2. The type 2 phosphatases can, in turn, be subdivided into three distinct enzymes—PP2A, PP2B, and PP2C by their dependence on divalent cations.
AB - This chapter discusses the classification of protein-serine/threonine phosphatases. These enzymes are divided into two groups—type 1 and type 2, depending on whether they dephosphorylate the β subunit of phosphorylase kinase specifically and are inhibited by nanomolar concentrations, or whether they dephosphorylate the α subunit of phosphorylase kinase preferentially and are insensitive to inhibitors 1 and 2. The type 2 phosphatases can, in turn, be subdivided into three distinct enzymes—PP2A, PP2B, and PP2C by their dependence on divalent cations.
UR - http://www.scopus.com/inward/record.url?scp=0025998844&partnerID=8YFLogxK
U2 - 10.1016/0076-6879(91)01035-Z
DO - 10.1016/0076-6879(91)01035-Z
M3 - Article
C2 - 1658556
AN - SCOPUS:0025998844
VL - 201
SP - 389
EP - 398
JO - Methods in Enzymology
JF - Methods in Enzymology
SN - 0076-6879
IS - C
ER -