Classifying general nonlinear force laws in cell-based models via the continuum limit

Philip J. Murray, Carina M. Edwards, Marcus J. Tindall, Philip K. Maini

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Although discrete cell-based frameworks are now commonly used to simulate a whole range of biological phenomena, it is typically not obvious how the numerous different types of model are related to one another, nor which one is most appropriate in a given context. Here we demonstrate how individual cell movement on the discrete scale modeled using nonlinear force laws can be described by nonlinear diffusion coefficients on the continuum scale. A general relationship between nonlinear force laws and their respective diffusion coefficients is derived in one spatial dimension and, subsequently, a range of particular examples is considered. For each case excellent agreement is observed between numerical solutions of the discrete and corresponding continuum models. Three case studies are considered in which we demonstrate how the derived nonlinear diffusion coefficients can be used to (a) relate different discrete models of cell behavior; (b) derive discrete, intercell force laws from previously posed diffusion coefficients, and (c) describe aggregative behavior in discrete simulations.
    Original languageEnglish
    Article number021921
    Number of pages11
    JournalPhysical Review E: Statistical, Nonlinear, and Soft Matter Physics
    Volume85
    Issue number2
    DOIs
    Publication statusPublished - 2012

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