Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics

Frances M. Brodsky, Beth L. Hill, Susan L. Acton, Inke Näthke, Darren H. Wong, Sreenivasan Ponnambalam, Peter Parham

    Research output: Contribution to journalArticlepeer-review

    80 Citations (Scopus)

    Abstract

    Polymerization of clathrin triskelions into clathrin coats and subsequent disassembly by the heat shock protein hsc70 control receptor-mediated pathways of intracellular transport. The clathrin light chains are major regulatory elements in these processes. These polypeptides consist of linear arrays of functional domains with distinctive sequence motifs. Comparison of unicellular and multicellular eukaryotes reveals differences in the numbers of clathrin light chains and in the functional domains they contain.
    Original languageEnglish
    Pages (from-to)208-213
    Number of pages6
    JournalTrends in Biochemical Sciences
    Volume16
    DOIs
    Publication statusPublished - 1991

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