Cleft lip and palate

Peter A. Mossey, Julian Little, Ron G. Munger, Mike J. Dixon, William C. Shaw

    Research output: Contribution to journalReview articlepeer-review

    743 Citations (Scopus)

    Abstract

    Clefts of the lip and palate are generally divided into two groups, isolated cleft palate and cleft lip with or without cleft palate, representing a heterogeneous group of disorders affecting the lips and oral cavity. These defects arise in about 1.7 per 1000 liveborn babies, with ethnic and geographic variation. Effects on speech, hearing, appearance, and psychology can lead to longlasting adverse outcomes for health and social integration. Typically, children with these disorders need multidisciplinary care from birth to adulthood and have higher morbidity and mortality throughout life than do unaffected individuals. This Seminar describes embryological developmental processes, epidemiology, known environmental and genetic risk factors, and their interaction. Although access to care has increased in recent years, especially in developing countries, quality of care still varies substantially. Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders. Technological advances and international collaborations have yielded some successes.

    Original languageEnglish
    Pages (from-to)1773-1785
    Number of pages13
    JournalLancet
    Volume374
    Issue number9703
    DOIs
    Publication statusPublished - 21 Nov 2009

    Keywords

    • NONSYNDROMIC ORAL CLEFTS
    • GENE-ENVIRONMENT INTERACTION
    • FOLIC-ACID FORTIFICATION
    • EDGE EPITHELIAL-CELLS
    • FACTOR-ALPHA-GENE
    • TRANSFORMING GROWTH FACTOR-BETA-3
    • MATERNAL FOLATE INTAKE
    • OROFACIAL CLEFTS
    • BIRTH-DEFECTS
    • CONGENITAL-ANOMALIES

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