Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults

Tanya Walsh (Lead / Corresponding author), Joseph L. Y. Liu, Paul Brocklehurst, Mark Lingen, Alexander R. Kerr, Graham Ogden, Saman Warnakulasuriya, Crispian Scully

    Research output: Contribution to journalArticle

    62 Citations (Scopus)
    190 Downloads (Pure)

    Abstract

    The objective of this review is to estimate the accuracy of the conventional oral examination (COE) used singly or in combination with another index test (Additional Table 1) as a screening test for the detection of oral cancer and potentially malignant disorders (PMD) of the lip and oral cavity of apparently healthy adults.

    The secondary objective of this review is to estimate the accuracy of the different tests with COE, when compared with each other.

    We will use meta-regression to explore possible sources of heterogeneity, ways in which the observed diagnostic test accuracy varies according to particular characteristics. Covariates to be included in these analyses will include.
    • Characteristics of the study sample: prevalence of carcinoma or PMD disease in the study (> 50% prevalence), inclusion of HPV + adults, tobacco users / high alcohol consumption.
    • Target condition (oral squamous cell carcinoma alone or oral squamous cell carcinoma and PMD).
    • Attributes of the screening programme: prospective organised or opportunistic, type of reference standard (examination and clinical evaluation by physician with specialist knowledge or extended follow-up), operator (dental or general practice professionals or other healthcare workers).

    This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2012, Issue 11. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.

    Original languageEnglish
    Article numberCD010173
    Pages (from-to)1-19
    Number of pages19
    JournalCochrane Database of Systematic Reviews
    Volume2012
    Issue number11
    DOIs
    Publication statusPublished - 14 Nov 2012

    Fingerprint

    Oral Diagnosis
    Mouth Neoplasms
    Mouth
    Squamous Cell Carcinoma
    Dental General Practices
    Databases
    Lip
    Routine Diagnostic Tests
    Alcohol Drinking
    Tobacco
    Cross-Sectional Studies
    Carcinoma
    Delivery of Health Care
    Physicians

    Keywords

    • Oral cancer
    • Diagnostic accuracy
    • Cochrane systematic review
    • Protocol
    • Screening

    Cite this

    Walsh, Tanya ; Liu, Joseph L. Y. ; Brocklehurst, Paul ; Lingen, Mark ; Kerr, Alexander R. ; Ogden, Graham ; Warnakulasuriya, Saman ; Scully, Crispian. / Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. In: Cochrane Database of Systematic Reviews. 2012 ; Vol. 2012, No. 11. pp. 1-19.
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    Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. / Walsh, Tanya (Lead / Corresponding author); Liu, Joseph L. Y.; Brocklehurst, Paul; Lingen, Mark; Kerr, Alexander R.; Ogden, Graham; Warnakulasuriya, Saman; Scully, Crispian.

    In: Cochrane Database of Systematic Reviews, Vol. 2012, No. 11, CD010173, 14.11.2012, p. 1-19.

    Research output: Contribution to journalArticle

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    AU - Liu, Joseph L. Y.

    AU - Brocklehurst, Paul

    AU - Lingen, Mark

    AU - Kerr, Alexander R.

    AU - Ogden, Graham

    AU - Warnakulasuriya, Saman

    AU - Scully, Crispian

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