Clinical associations of mucus plugging in moderate to severe asthma

Rory Chan, Chary Duraikannu, Brian Lipworth (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
90 Downloads (Pure)

Abstract

Background: Mucus plugging is recognized as a contributory factor to airway obstruction and symptoms in persistent asthma. Objective: We aimed to determine phenotypic associations of mucus plugging in patients with moderate to severe asthma in a real-life clinic setting.

Methods: Mucus plugs (MPs) were identified by a thoracic radiologist upon high-resolution computed tomography imaging. A MP score was subsequently calculated and analyzed along with type 2 biomarkers, spirometry, severe exacerbations, and asthma control for 126 patients with moderate to severe asthma before biologic therapy.

Results: Asthma patients with MP had significantly worse FEV 1%, forced expiratory flow at 25% to 75% of FVC percent, and FEV 1/FVC as well as higher levels of peripheral blood eosinophils, FeNO, total IgE, and Aspergillus fumigatus IgE titers, and had previously experienced more frequent severe exacerbations. FEV 1/FVC, more than two exacerbations per year, blood eosinophils, total IgE, and A fumigatus IgE titers were associated with MPs after adjusting for confounders.

Conclusions: Poorly controlled asthma patients with MPs exhibited significantly worse airflow obstruction and greater type 2 inflammation associated with more frequent severe exacerbations. Impaired spirometry, more frequent exacerbations, raised blood eosinophils, total IgE, and A fumigatus IgE increased the likelihood of MPs.

Original languageEnglish
Pages (from-to)195-199.e2
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology: In Practice
Volume11
Issue number1
Early online date21 Sept 2022
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Airway obstruction
  • Asthma
  • Eosinophils
  • Exacerbations
  • Mucus plugging
  • Type 2 inflammation

ASJC Scopus subject areas

  • Immunology and Allergy

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