Abstract
Background: In the year 2035, projections have estimated that 5% of the Scottish population will be morbidly obese defined as a body mass index (BMI) greater than or equal to 40 kg/m 2. Airway oscillometry is an effort-independent test akin to bronchial sonar which measures resistance and compliance.
Objective: To evaluate the impact of obesity on lung mechanics using oscillometry.
Methods: Clinical data for 188 patients with respiratory physician–diagnosed moderate-to-severe asthma were retrospectively collected and analyzed.
Results: Obesity (BMI 30-39.9 kg/m 2) and morbid obesity (BMI ≥ 40 kg/m 2) were associated with a significantly worse heterogeneity of peripheral resistance between 5 Hz and 20 Hz and peripheral compliance as low-frequency reactance at 5 Hz and area under the reactance curve, as compared with normal weight (BMI 18.5-24.9 kg/m 2). Cluster analysis incorporating oscillometry identified a patient cohort who was older, obese, and female with combined impairment of spirometry and oscillometry coupled with more frequent severe exacerbations.
Conclusion: Obesity is associated with worse peripheral airway dysfunction in moderate-to-severe asthma, including a patient cluster who was older, obese, and female with more frequent exacerbations.
Original language | English |
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Pages (from-to) | 338-342.e3 |
Number of pages | 6 |
Journal | Annals of Allergy, Asthma and Immunology |
Volume | 131 |
Issue number | 3 |
Early online date | 18 May 2023 |
DOIs | |
Publication status | Published - Sept 2023 |
Keywords
- obesity
- body mass index
- oscillometry
- asthma
- cluster analysis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Immunology and Allergy
- Immunology